ArticleParasites & vectors2018
The Nix locus on the male-specific homologue of chromosome 1 in Aedes albopictus is a strong candidate for a male-determining factor.
Article in Parasites & vectors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- The evolution of reproduction without blood feeding in an invasive vector mosquito Aedes albopictus.BMC biology · 2026Article
- Distinct Swimming Behaviours in Pupae ofEcology and evolution · 2026Article
- Article
- Developmental and Nutritional Dynamics of Malpighian Tubule Autofluorescence in the Asian Tiger MosquitoInternational journal of molecular sciences · 2023Article
- Selective targeting of biting females to control mosquito-borne infectious diseases.Trends in parasitology · 2022Review
- Transgenic expression of Nix converts genetic females into males and allows automated sex sorting in Aedes albopictus.Communications biology · 2022Article
- A Conserved Female-Specific Requirement for thePathogens (Basel, Switzerland) · 2022Article
- Manipulating Insect Sex Determination Pathways for Genetic Pest Management: Opportunities and Challenges.Frontiers in bioengineering and biotechnology · 2022Review
- A conserved female-specific larval requirement for MtnB function facilitates sex separation in multiple species of disease vector mosquitoes.Parasites & vectors · 2021Article
- A Linkage-Based Genome Assembly for the MosquitoInsects · 2021Article
- Improved reference genome of the arboviral vector Aedes albopictus.Genome biology · 2020Article
- Nix is a male-determining factor in the Asian tiger mosquito Aedes albopictus.Insect biochemistry and molecular biology · 2020Article
- Joint FAO/IAEA Coordinated Research Project on "Exploring genetic, molecular, mechanical and behavioural methods of sex separation in mosquitoes" - an introduction.Parasites & vectors · 2018Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlobal concern over the rapid expansion of the Asian tiger mosquito, Aedes albopictus, and its vector competence has highlighted an urgent need to improve currently available population control methods, like the Sterile Insect Technique. Knowledge of the sex determination cascade is a prerequisite for the development of early-stage sexing systems. To this end, we have characterised the putative sex determination gene, Nix, in this species. In Aedes species the chromosome complement consists of three pairs of chromosomes. The sex determination alleles are linked to the smallest homomorphic chromosome.
resultsWe identified the male-specific chromosome 1 of Ae. albopictus that carries the putative male-determining gene Nix. We have also characterised the complete genomic sequence of the Nix gene which is composed of two exons and a short intron. The gene displays different levels of intron retention during development. Comparison of DNA sequences covering most of the Nix gene from individuals across the species range revealed no polymorphism.
conclusionsOur characterisation of the Nix gene in Ae. albopictus represents an initial step in the analysis of the sex determination cascade in this species. We found evidence of intron retention (IR) in Nix. IR might play a role in regulating the expression of Nix during development. Our results provide the basis for the development of new genetic control strategies.
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