ArticleAsian Pacific journal of cancer prevention : APJCP2018
Enzymatic Antioxidant and Lipid Peroxidation Evaluation in the Newly Diagnosed Breast Cancer Patients in Iran
Article in Asian Pacific journal of cancer prevention : APJCP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Lipid peroxidation in cancer: a double-edged sword shaping progression and therapy.Medical oncology (Northwood, London, England) · 2026Review
- The metformin administration on pancreatic tissue damage in metastatic rat prostate cancer and STZ induced diabetes model.Journal of molecular histology · 2025Article
- Green-Synthesized Silver Nanoparticles UsingAntioxidants (Basel, Switzerland) · 2025Article
- GSTP1, PRDX2 and NFE2L2: Potential Markers for Primary Stage Breast Cancer.Current drug targets · 2025Article
- Chemotherapy on hematological and biochemical parameters in breast cancer patients.Caspian journal of internal medicine · 2025Article
- Assessment of lipid peroxidation and total antioxidant capacity in patients with breast cancer.Exploration of targeted anti-tumor therapy · 2025Article
- Studies on the association of malondialdehyde as a biomarker for oxidative stress and degree of malignancy in dogs with mammary adenocarcinomas.Veterinary medicine and science · 2024Article
- Identifying the predictive role and the related drugs of oxidative stress genes in the hepatocellular carcinoma.Cancer reports (Hoboken, N.J.) · 2024Article
- Role of Natural Antioxidants in Cancer.Cancer treatment and research · 2024Review
- The Nephroprotective Activity ofJournal of experimental pharmacology · 2024Article
- Article
- Fermented Soy Products and Their Potential Health Benefits: A Review.Microorganisms · 2022Review
- Dihydromyricetin ameliorates oxygen‑glucose deprivation and re‑oxygenation‑induced injury in HT22 cells by activating the Wnt/β‑catenin signaling pathway.Molecular medicine reports · 2022Article
- An Oxidative Stress-Related Genes Signature for Predicting Survival in Bladder Cancer: Based on TCGA Database and Bioinformatics.International journal of general medicine · 2022Article
- Association between Oxidative Stress Parameters and Hematological Indices in Breast Cancer Patients.International journal of breast cancer · 2022Article
- GC-MS Analysis of Potentially Volatile Compounds ofFrontiers in microbiology · 2022Article
- The Therapeutic Potential of Aprepitant in Glioblastoma Cancer Cells through Redox Modification.BioMed research international · 2022Article
- Therapeutic Influence on Important Targets Associated with Chronic Inflammation and Oxidative Stress in Cancer Treatment.Cancers · 2021Review
- High density lipoproteins and oxidative stress in breast cancer.Lipids in health and disease · 2021Review
- Phloretin Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by Regulating the Inflammatory Response, Oxidative Stress and Apoptosis.Life (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors.
Funding
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Abstract
Background: Breast cancer is caused by breast tissue malignant cells and it has become one of the main medical concerns with a socio-economic significance especially for women. Among the multiple factors involved in the initiation, progression, and invasion of breast cancer, oxidative stress plays an important role. Antioxidant status, lipid peroxidation, and oxidative stress in newly diagnosed breast cancer patients were determined to find a defined pattern of oxidative stress in these patients. Methods: The malondialdehyde (MDA) levels (as an indicator of lipid peroxidation), glutathione peroxidase (GPX), and superoxide dismutase (SOD) activities of newly diagnosed breast cancer patients (n=38) and controls (n=38) were assessed using blood samples. Results: MDA level and SOD activity were significantly higher in the breast cancer patients compared to the healthy subjects group (p<0.05). Compared to the healthy group, GPX activity decreased significantly in patients group (p<0.05). Conclusions: High lipid peroxidation is an important risk factor for breast cancer and the increased levels of superoxide anion in breast cancer cells may be a reason for the induction of SOD activity. Nevertheless, oxidative stress is an important factor in development and progression of breast cancer. Further studies on it can lead to a more helpful approach to management of breast cancer.
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