Evidence map›Paper›PMID 30583584›Full record

ArticleInternational journal of molecular sciences2018

Invasive Colon Cancer Cells Induce Transdifferentiation of Endothelium to Cancer-Associated Fibroblasts through Microtubules Enriched in Tubulin-β3.

Marta Ewelina Wawro, Katarzyna Chojnacka, Katarzyna Wieczorek-Szukała, Katarzyna Sobierajska, Jolanta Niewiarowska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  18. Endothelial-to-Mesenchymal Transition in Cancer.Frontiers in cell and developmental biology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marta Ewelina WawroDepartment of Molecular Cell Mechanisms, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland. marta.wawro@umed.lodz.pl.
Katarzyna ChojnackaDepartment of Molecular Cell Mechanisms, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland. katarzyna.chojnacka@stud.umed.lodz.pl.
Katarzyna Wieczorek-SzukałaDepartment of Molecular Cell Mechanisms, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland. katarzyna.wieczorek@umed.lodz.pl.
Katarzyna SobierajskaDepartment of Molecular Cell Mechanisms, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland. katarzyna.sobierajska@umed.lodz.pl.
Jolanta NiewiarowskaDepartment of Molecular Cell Mechanisms, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland. jolanta.niewiarowska@umed.lodz.pl.ORCID 0000-0003-0561-7766

Funding

Medical University of Lodz 502-03/6-171-02/502-64-098Narodowe Centrum Badań i Rozwoju Pol-Nor/209521/5/2013
6 · The paper itself

Abstract

Colon cancer, the second leading cause of cancer-related deaths in the world, is usually diagnosed in invasive stages. The interactions between cancer cells and cells located in their niche remain the crucial mechanism inducing tumor metastasis. The most important among those cells are cancer-associated fibroblasts (CAFs), the heterogeneous group of myofibroblasts transdifferentiated from numerous cells of different origin, including endothelium. The endothelial-to-mesenchymal transition (EndMT) is associated with modulation of cellular morphology, polarization and migration ability as a result of microtubule cytoskeleton reorganization. Here we reveal, for the first time, that invasive colon cancer cells regulate EndMT of endothelium via tubulin-β3 upregulation and its phosphorylation. Thus, we concluded that therapies based on inhibition of tubulin-β3 expression or phosphorylation, or blocking tubulin-β3's recruitment to the microtubules, together with anti-inflammatory chemotherapeutics, are promising means to treat advanced stages of colon cancer.

Indexed as

Cell TransdifferentiationCancer-Associated FibroblastsCell Line, TumorColonic NeoplasmsEndotheliumEnzyme InhibitorsHumansMicrotubulesNeoplasm InvasivenessPhosphorylationTransforming Growth Factor betaTubulinUp-RegulationWortmanninEnzyme InhibitorsTransforming Growth Factor betaTubulinWortmanninCAFsTGF-βstubulin-β3

Identifiers

PMID30583584
PMCPMC6337286

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.