Evidence map›Paper›PMID 30583557›Full record

ArticleGenes2018

The Alkaline Phosphatase (ALPL) Locus Is Associated with B6 Vitamer Levels in CSF and Plasma.

Loes M Loohuis, Monique Albersen, Simone de Jong, Timothy Wu, Jurjen J Luykx, Judith J M Jans, Nanda M Verhoeven-Duif, Roel A Ophoff

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Scientific opinion on the tolerable upper intake level for vitamin B6.EFSA journal. European Food Safety Authority · 2023
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Loes M LoohuisCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA. loldeloohuis@mednet.ucla.edu.ORCID 0000-0002-3327-7837
Monique AlbersenSection Metabolic Diagnostics, Department of Genetics, University Medical Center (UMC), 3584 EA, Utrecht, The Netherlands. m.albersen@vumc.nl.
Simone de JongCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA. sdejongwork@gmail.com.
Timothy WuCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA. Timothy.Wu@bcm.edu.ORCID 0000-0001-5296-2023
Jurjen J LuykxDepartment of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center (UMC), 3584 CG, Utrecht, The Netherlands. jjluykx@gmail.com.ORCID 0000-0002-6439-2774
Judith J M JansSection Metabolic Diagnostics, Department of Genetics, University Medical Center (UMC), 3584 EA, Utrecht, The Netherlands. J.J.M.Jans@umcutrecht.nl.
Nanda M Verhoeven-DuifSection Metabolic Diagnostics, Department of Genetics, University Medical Center (UMC), 3584 EA, Utrecht, The Netherlands. N.Verhoeven@umcutrecht.nl.
Roel A OphoffCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA. ROphoff@mednet.ucla.edu.
University Medical Center Utrecht · NLUniversity of California, Los Angeles · US

Funding

Training Grant in Neurobehavioral GeneticsT32NS048004 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, OPHOFF, ROEL A · 2004 to 2025
$5.8M
Genetics of CSF Metabolites in Alzheimer Disease and other Brain DisordersRF1AG058484 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OPHOFF, ROEL A · 2018 to 2018
$3.8M
Accelerating the diagnosis of bipolar disorder using genetic and phenotypic signaturesK99MH116115 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLDE LOOHUIS, LOES MARLEIN · 2018 to 2019
$257k
National Institute of Mental Health K99MH116115National Institute of Neurological Disorders and Stroke T32NS048004National Institute on Aging RF1 AG058484
6 · The paper itself

Abstract

The active form of vitamin B6, pyridoxal phosphate (PLP), is essential for human metabolism. The brain is dependent on vitamin B6 for its neurotransmitter balance. To obtain insight into the genetic determinants of vitamin B6 homeostasis, we conducted a genome-wide association study (GWAS) of the B6 vitamers pyridoxal (PL), PLP and the degradation product of vitamin B6, pyridoxic acid (PA). We collected a unique sample set of cerebrospinal fluid (CSF) and plasma from the same healthy human subjects of Dutch ancestry (

Indexed as

cerebrospinal fluidgenome wide association studyplasmavitamin B6

Identifiers

PMID30583557
PMCPMC6357176
OpenAlexW2906077065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.