ArticleCell and tissue research1988
Cytoskeletons of retinal pigment epithelial cells: interspecies differences of expression patterns indicate independence of cell function from the specific complement of cytoskeletal proteins.
Article in Cell and tissue research, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 82 citations in OpenAlex.
- Organotypic Culture of Adult Vascularized Porcine Retina Explants In Vitro on Nanotube Scaffolds.Biological procedures online · 2025Article
- Desmosome and Hemidesmosome Disassembly in Retinal Pigmented Epithelium: Intersection with the Exosome Pathway.Advances in experimental medicine and biology · 2025Review
- Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish.Nature communications · 2021Article
- The Cytoskeleton of the Retinal Pigment Epithelium: from Normal Aging to Age-Related Macular Degeneration.International journal of molecular sciences · 2019Review
- Identity of pigmented subretinal cells in age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2016Article
- Laser photocoagulation enhances adeno-associated viral vector transduction of mouse retina.Human gene therapy methods · 2014Article
- Expression and role of VEGF in the adult retinal pigment epithelium.Investigative ophthalmology & visual science · 2011Article
- Transcriptomic analysis of human retinal detachment reveals both inflammatory response and photoreceptor death.PloS one · 2011Article
- Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye.The Journal of cell biology · 2004Article
- Oncogenic regulation and function of keratins 8 and 18.Cancer metastasis reviews · 1996Review
- Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules.The Journal of cell biology · 1995Article
- Cytokeratin-containing cells in proliferative diabetic retinopathy membranes.The British journal of ophthalmology · 1994Article
- Ultrastructural localization of RPE-associated epitopes recognized by monoclonal antibodies in human RPE and their induction in human fibroblasts by vitreous.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 1993Article
- Characterization of bovine ciliary pigmented epithelial cells in monolayer culture: an ultrastructural, enzyme histochemical and immunohistochemical study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 1993Article
- Intermediate filament protein expression and mesoderm formation in the rabbit embryo : A double-labelling immunofluorescence study.Roux's archives of developmental biology : the official organ of the EDBO · 1992Article
- Regional differences in the distribution of cytoskeletal filaments in the human and bovine ciliary epithelium.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 1992Article
- Polarized and functional epithelia can form after the targeted inactivation of both mouse keratin 8 alleles.The Journal of cell biology · 1991Article
- Heterogeneity in the immunolocalization of cytokeratin specific monoclonal antibodies in the rat eye: evaluation of unusual epithelial tissue entities.Histochemistry · 1991Article
- Morphological changes in the zonula adhaerens during embryonic development of chick retinal pigment epithelial cells.Cell and tissue research · 1990Article
- An epithelium-type cytoskeleton in a glial cell: astrocytes of amphibian optic nerves contain cytokeratin filaments and are connected by desmosomes.The Journal of cell biology · 1989Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vertebrate tissue development a given cell differentiation pathway is usually associated with a pattern of expression of a specific set of cytoskeletal proteins, including different intermediate filament (IF) and junctional proteins, which is identical in diverse species. The retinal pigment epithelium (RPE) is a layer of polar cells that have very similar morphological features and practically identical functions in different vertebrate species. However, in biochemical and immunolocalization studies of the cytoskeletal proteins of these cells we have noted remarkable interspecies differences. While chicken RPE cells contain only IFs of the vimentin type and do not possess desmosomes and desmosomal proteins RPE cells of diverse amphibian (Rana ridibunda, Xenopus laevis) and mammalian (rat, guinea pig, rabbit, cow, human) species express cytokeratins 8 and 18 either as their sole IF proteins, or together with vimentin IFs as in guinea pig and a certain subpopulation of bovine RPE cells. Plakoglobin, a plaque protein common to desmosomes and the zonula adhaerens exists in RPE cells of all species, whereas desmoplakin and desmoglein have been identified only in RPE desmosomes of frogs and cows, including bovine RPE cell cultures in which cytokeratins have disappeared and vimentin IFs are the only IFs present. These challenging findings show that neither cytokeratin IFs nor desmosomes are necessary for the establishment and function of a polar epithelial cell layer and that the same basic cellular architecture can be achieved by different programs of expression of cytoskeletal proteins. The differences in the composition of the RPE cytoskeleton further indicate that, at least in this tissue, a specific program of expression of IF and desmosomal proteins is not related to the functions of the RPE cell, which are very similar in the various species.
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