ArticleOsteoarthritis and cartilage2019
The impact of painful knee osteoarthritis on mortality: a community-based cohort study with over 24 years of follow-up.
Article in Osteoarthritis and cartilage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06195423 (The Stop Osteoarthritis), which is not on this map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Stop Osteoarthritis (SOAR) Hybrid Effectiveness-Implementation Type 1 Randomized Controlled Trial for Young People At-High-Risk of Early Onset Knee Osteoarthritis
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Mortality risk in osteoarthritis patients: a meta-analysis of observational studies.BMC musculoskeletal disorders · 2025Pooled it
- Knee osteoarthritis and time-to all-cause mortality in six community-based cohorts: an international meta-analysis of individual participant-level data.Aging clinical and experimental research · 2021Pooled it
- Short-Term Efficacy of High-Intensity Laser Therapy in Alleviating Pain in Patients with Knee Osteoarthritis: A Single-Blind Randomised Controlled Trial.Pain research & management · 2022Trial
- Obesity-Associated Osteoarthritis: Mechanical-Metabolic Pathogenesis, Obesity Memory and Dual-Target Therapy.Current obesity reports · 2026Review
- A roadmap for developing a program to self-manage post-traumatic knee osteoarthritis risk.Osteoarthritis and cartilage open · 2026Article
- The Relation of Within-Day Physical Activity Patterns With All-Cause Mortality in Adults With Knee Osteoarthritis: Findings From the Osteoarthritis Initiative.Arthritis care & research · 2026Observational
- The impact of knee osteoarthritis on cardiovascular disease mortality: A systematic review and meta-analysis.Osteoarthritis and cartilage open · 2026Review
- Physical activity and joint health: Implications for knee osteoarthritis disease pathophysiology and mechanics.Experimental physiology · 2026Review
- A Painful Reality Check? Examining the Accuracy of Subjective Survival Probabilities by Pain Interference and Depression Status.Journal of aging and health · 2026Article
- Pain Phenotype in Knee Osteoarthritis: Implications for Mechanism-Based Therapy.Orthopaedic surgery · 2025Review
- Prevalence of radiographic knee osteoarthritis in China: a national survey of thirty thousand, four hundred and fifty five individuals cross-sectional study.International orthopaedics · 2025Article
- Levels of catastrophizing pain and kinesiophobia in patients with osteoarthritis and their association.European journal of translational myology · 2025Article
- Article
- Associations of Physical Activity, Sedentary Behaviour, Pain, Function and Quality of Life With Diabetes and Knee Osteoarthritis: Data From the Osteoarthritis Initiative.Musculoskeletal care · 2025Article
- Subjective geriatric complaints as predictors of disability and mortality in community-dwelling older adults: a 5-year cohort study.Age and ageing · 2025Article
- Next-Level Prediction of Structural Progression in Knee Osteoarthritis: A Perspective.International journal of molecular sciences · 2025Review
- Risk of all-cause mortality in patients with knee osteoarthritis: A systematic review and meta-analysis of cohort studies.Osteoarthritis and cartilage open · 2025Review
- Article
- Postoperative joint pain is associated with long-term all-cause mortality after total joint arthroplasty.PloS one · 2025Article
- A Comparative Study Between Ultrasound-Guided Genicular Nerve Block Combined With Interspace Between the Popliteal Artery and the Capsule of the Posterior Knee Block versus Adductor Canal Block in Total Knee Replacement.Anesthesiology research and practice · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo investigate the impact of knee osteoarthritis (OA) and/or knee pain on excess mortality.
methodWe analyzed data from 4,182 participants in a community-based prospective cohort study of African American and Caucasian men and women aged ≥45 years. Participants completed knee radiographs and questionnaires at baseline and at up to three follow-ups to determine knee OA (rOA), knee pain and covariate status. Mortality was determined through 2015. We used Cox proportional hazards regression with time-varying covariates (TVC) to estimate hazard ratios (HR) and 95% confidence intervals (CI). Additional analyses stratified by sex, race and age were carried out.
resultsMedian follow-up time was 14.6 years during which 1822 deaths occurred. Baseline knee radiographic osteoarthritis (rOA) was 27.7%, 38.8% at first follow-up, 52.6% at second follow-up and 61.9% at the third follow-up. Knee rOA with pain and knee pain alone were both associated with a >15% increase in premature all-cause mortality. In analyses stratified by sex, race and age, associations between knee pain, with or without knee rOA, and all-cause death were found among women, Caucasians, those ≤65 years of age, and those with a body mass index (BMI)≥30, with observed increased risks of death between 21% and 65%. We observed similar, somewhat attenuated, results for cardiovascular disease (CVD) deaths.
conclusionIn models taking into account variables that change over time, individuals who had knee pain, alone or with knee rOA, had increased mortality. These effects were particularly strong among those obese. Effective interventions to reduce knee pain, particularly those including weight management and prevention of comorbidities, could reduce mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.