Evidence map›Paper›PMID 30582946›Full record

ArticleToxicology and applied pharmacology2019

Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing.

Erin Madeen, Lisbeth K Siddens, Sandra Uesugi, Tammie McQuistan, Richard A Corley, Jordan Smith, Katrina M Waters, Susan C Tilton, Kim A Anderson, Ted Ognibene and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023
    Review
  5. HPLC-Parallel accelerator and molecular mass spectrometry analysis ofJournal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2023
    Article
  6. Article
  7. Article
  8. Detection of Benzo[Toxics · 2022
    Article
  9. Article
  10. Article
  11. 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans.Drug metabolism and disposition: the biological fate of chemicals · 2021
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Erin MadeenDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA; NIEHS Superfund Research Program, Oregon State University, Corvallis, OR, USA.
Lisbeth K SiddensDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA; NIEHS Superfund Research Program, Oregon State University, Corvallis, OR, USA; Linus Pauling Institute, Oregon State University, Corvallis, OR, USA.
Sandra UesugiLinus Pauling Institute, Oregon State University, Corvallis, OR, USA.
Tammie McQuistanWestern University of Health Sciences, Lebanon, OR, USA.
Richard A CorleyNIEHS Superfund Research Program, Oregon State University, Corvallis, OR, USA; Chemical Biology and Exposure Science, Pacific Northwest National Laboratory, Richland, WA, USA.
Jordan SmithNIEHS Superfund Research Program, Oregon State University, Corvallis, OR, USA; Chemical Biology and Exposure Science, Pacific Northwest National Laboratory, Richland, WA, USA.
Katrina M WatersNIEHS Superfund Research Program, Oregon State University, Corvallis, OR, USA; Chemical Biology and Exposure Science, Pacific Northwest National Laboratory, Richland, WA, USA.
Susan C TiltonDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA; NIEHS Superfund Research Program, Oregon State University, Corvallis, OR, USA.
Kim A AndersonDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA; NIEHS Superfund Research Program, Oregon State University, Corvallis, OR, USA.
Ted OgnibeneCenter for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, CA, USA.
Kenneth TurteltaubCenter for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, CA, USA; Biology and Biotechnology Research Division, Lawrence Livermore National Laboratory, Livermore, CA, USA.
David E WilliamsDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA; NIEHS Superfund Research Program, Oregon State University, Corvallis, OR, USA; Linus Pauling Institute, Oregon State University, Corvallis, OR, USA. Electronic address: david.williams@oregonstate.edu.
Oregon State University · USLawrence Livermore National Laboratory · USWestern University of Health Sciences · US

Funding

Research Experience and Training Coordination CoreP42ES016465 · NIEHS · OREGON STATE UNIVERSITY · PI Robyn L Tanguay · 2009 to 2026
$52.5M
Resource for the Development of Biomedical Accelerator Mass Spectrometry (AMS)P41GM103483 · NIGMS · UNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB · PI TURTELTAUB, KENNETH W. · 2012 to 2019
$12.0M
MODE OF ACTION OF ENVIRONMENTAL TOXICANTST32ES007060 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt, Siva Kumar Kolluri · 1985 to 2026
$11.6M
Benzo[a]pyrene Micro-dosing of Humans: A New Tool for Exposure, Risk Assessment and PreventionR01ES028600 · NIEHS · OREGON STATE UNIVERSITY · PI WILLIAMS, DAVID E · 2018 to 2022
$2.5M
NIEHS NIH HHS P42 ES016465NIEHS NIH HHS R01 ES028600NIEHS NIH HHS T32 ES007060NIGMS NIH HHS P41 GM103483
6 · The paper itself

Abstract

Benzo[a]pyrene (BaP), is a known human carcinogen (International Agency for Research on Cancer (IARC) class 1). The remarkable sensitivity (zepto-attomole

Indexed as

Mass SpectrometryAdministration, OralAdultAgedBenzo(a)pyreneCarcinogensChromatography, LiquidCytochrome P-450 CYP1B1DNA AdductsFemaleGlutathione TransferaseHumansMaleMiddle AgedModels, BiologicalPharmacogenomic VariantsBenzo(a)pyreneCarcinogensCYP1B1 protein, humanCytochrome P-450 CYP1B1DNA AdductsGlutathione TransferaseAccelerator mass spectrometryBenzo[a]pyreneMetabolitesMicro-dosingPharmacokineticsPolycyclic aromatic hydrocarbons

Identifiers

PMID30582946
PMCPMC6369707
OpenAlexW2905598960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.