Evidence map›Paper›PMID 30582748›Full record

ArticleJournal of neurochemistry2019

The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A.

Anna Stepanova, Csaba Konrad, Giovanni Manfredi, Roger Springett, Vadim Ten, Alexander Galkin

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Rescuing Ischemic Brain Injury by Rewiring Mitochondrial Electron Flow.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Understanding coenzyme Q.Physiological reviews · 2024
    Review
  7. SCAF1 drives the compositional diversity of mammalian respirasomes.Nature structural & molecular biology · 2024
    Article
  8. Review
  9. Molecules (Basel, Switzerland) · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Metabolic ROS Signaling: To Immunity and Beyond.Biochemistry. Biokhimiia · 2020
    Review
  17. Measurement of mitochondrial HMethods in cell biology · 2020
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Anna StepanovaQueen's University Belfast, School of Biological Sciences, Medical Biology Centre, Belfast, UK.
Csaba KonradFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Giovanni ManfrediFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Roger SpringettCardiovascular Division, King's College London, British Heart Foundation Centre of Excellence London, London, UK.
Vadim TenDepartment of Pediatrics, Columbia University, New York, NY, USA.
Alexander GalkinQueen's University Belfast, School of Biological Sciences, Medical Biology Centre, Belfast, UK.ORCID 0000-0001-8469-2283
Cornell University · USQueen's University Belfast · GBColumbia University · USKing's College London · GB

Funding

Mitochondrial complex-I as a target for metabolic resuscitation in perinatal hypoxic-ischemic brain injuryR01NS100850 · NINDS · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI TEN, VADIM S · 2017 to 2021
$2.0M
Estrogen receptor beta and mitochondrial permeability transition in Ca2+-induced neuronal injuryR01NS095692 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO, MANFREDI, GIOVANNI · 2016 to 2020
$1.9M
Medical Research Council MR/L007339/1MRC MR/L007339/1NINDS NIH HHS R01 NS095692NINDS NIH HHS R01 NS100850
6 · The paper itself

Abstract

Reactive oxygen species (ROS) are by-products of physiological mitochondrial metabolism that are involved in several cellular signaling pathways as well as tissue injury and pathophysiological processes, including brain ischemia/reperfusion injury. The mitochondrial respiratory chain is considered a major source of ROS; however, there is little agreement on how ROS release depends on oxygen concentration. The rate of H

Indexed as

AnimalsAntimycin ABrainCell HypoxiaCell RespirationElectron-Transferring FlavoproteinsEnergy MetabolismMiceMitochondriaOxygenOxygen ConsumptionReactive Oxygen SpeciesAntimycin AElectron-Transferring FlavoproteinsOxygenReactive Oxygen Speciesantimycin Acomplex Iischemia/reperfusionmitochondriareverse electron transferROS generation

Identifiers

PMID30582748
PMCPMC7086484
OpenAlexW2906000816

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.