Evidence map›Paper›PMID 30582519›Full record

ArticleeLife2018

Mechanisms of opening and closing of the bacterial replicative helicase.

Jillian Chase, Andrew Catalano, Alex J Noble, Edward T Eng, Paul Db Olinares, Kelly Molloy, Danaya Pakotiprapha, Martin Samuels, Brian Chait, Amedee des Georges and 1 more

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Mechanisms of hexameric helicases.Critical reviews in biochemistry and molecular biology · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. A structural view of bacterial DNA replication.Protein science : a publication of the Protein Society · 2019
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jillian ChaseDepartment of Chemistry and Biochemistry, City College of New York, New York, United States.ORCID http://orcid.org/0000-0002-1027-6516
Andrew CatalanoDepartment of Chemistry and Biochemistry, City College of New York, New York, United States.
Alex J NobleSimons Electron Microscopy Center, The New York Structural Biology Center, New York, United States.ORCID http://orcid.org/0000-0001-8634-2279
Edward T EngSimons Electron Microscopy Center, The New York Structural Biology Center, New York, United States.ORCID http://orcid.org/0000-0002-8014-7269
Paul Db OlinaresLaboratory for Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, United States.
Kelly MolloyLaboratory for Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, United States.
Danaya PakotipraphaDepartment of Biochemistry, Center for Excellence in Protein and Enzyme Technology, Faculty of Science, Mahidol University, Bangkok, Thailand.ORCID http://orcid.org/0000-0002-5017-8283
Martin SamuelsDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, United States.
Brian ChaitLaboratory for Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, United States.
Amedee des GeorgesDepartment of Chemistry and Biochemistry, City College of New York, New York, United States.
David JeruzalmiDepartment of Chemistry and Biochemistry, City College of New York, New York, United States.ORCID http://orcid.org/0000-0001-5886-1370

Funding

TR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8M
TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX · 2012 to 2021
$14.7M
Cellular/Molecular Basis of Development: Research CenterG12MD007603 · NIMHD · CITY COLLEGE OF NEW YORK · PI PEZZANO, MARK · 2012 to 2017
$11.5M
National Resource for Mass Spectrom of Biological MacromoleculesP41GM103314 · NIGMS · ROCKEFELLER UNIVERSITY · PI CHAIT, BRIAN T · 2012 to 2017
$9.9M
Replication Initiation in Bacteria and EukaryotesR01GM084162 · NIGMS · HARVARD UNIVERSITY · PI JERUZALMI, DAVID · 2009 to 2012
$1.5M
Acquisition of Detector for JEOL 3200 FSC Electron MicroscopeS10OD019994 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI CARRAGHER, BRIDGET OLIVIA · 2015 to 2015
$600k
Structural Studies of Type II Cadherins on Membranes by Cryo-Electron TomographyF32GM128303 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI NOBLE, ALEX JAMES · 2018 to 2019
$120k
NIGMS NIH HHS F32 GM128303NIGMS NIH HHS P41 GM103310NIGMS NIH HHS P41 GM103314NIGMS NIH HHS P41 GM109824NIGMS NIH HHS R01 GM084162NIH HHS 5G12MD007603-30NIH HHS F32GM128303NIH HHS GM084162NIH HHS OD019994NIH HHS P41 GM103314NIH HHS P41 GM109824NIH HHS S10 OD019994NIMHD NIH HHS G12 MD007603
6 · The paper itself

Abstract

Assembly of bacterial ring-shaped hexameric replicative helicases on single-stranded (ss) DNA requires specialized loading factors. However, mechanisms implemented by these factors during opening and closing of the helicase, which enable and restrict access to an internal chamber, are not known. Here, we investigate these mechanisms in the

Indexed as

DNA ReplicationBacteriophage lambdaCryoelectron MicroscopyDnaB HelicasesDNA, Single-StrandedEscherichia coliModels, MolecularProtein BindingProtein ConformationViral ProteinsDnaB HelicasesdnaB protein, E coliDNA replication complex protein, Bacteriophage lambdaDNA, Single-StrandedViral Proteinsbiochemistrychemical biologycryogenic electron microscopyDnaB replicative helicaseDNA replicationE. colihelicase loadermolecular biophysicsreplication initiationstructural biology

Identifiers

PMID30582519
PMCPMC6391071

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.