Evidence map›Paper›PMID 30582407›Full record

SynthesisJournal of toxicology and environmental health. Part B, Critical reviews2018

Environmental contaminants and preeclampsia: a systematic literature review.

Emma M Rosen, Mg Isabel Muñoz, Thomas McElrath, David E Cantonwine, Kelly K Ferguson

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of toxicology and environmental health. Part B, Critical reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 6 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 6 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Maternal Mercury Exposure and Hypertensive Disorders of Pregnancy: A Systematic Review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022
    Pooled it
  7. Article
  8. Review
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  11. Gestational arsenite exposure alters maternal postpartum heart size and induces CaAmerican journal of physiology. Heart and circulatory physiology · 2025
    Article
  12. Article
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  15. Article
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  17. Article
  18. Effect of the Aqueous Extract ofCurrent issues in molecular biology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Emma M Rosena Epidemiology Branch , National Institute of Environmental Health Sciences, Research Triangle Park , NC , USA.
Mg Isabel Muñoza Epidemiology Branch , National Institute of Environmental Health Sciences, Research Triangle Park , NC , USA.
Thomas McElrathb Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , Brigham and Women's Hospital , Boston , MA , USA.
David E Cantonwineb Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , Brigham and Women's Hospital , Boston , MA , USA.
Kelly K Fergusona Epidemiology Branch , National Institute of Environmental Health Sciences, Research Triangle Park , NC , USA.
National Institute of Environmental Health Sciences · USBrigham and Women's Hospital · US

Funding

LIFECODES pregnancy cohortZIAES103321 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI FERGUSON, KELLY · 2016 to 2025
$6.1M
Intramural NIH HHS ZIA ES103321
6 · The paper itself

Abstract

Preeclampsia is a medical condition specific to pregnancy characterized by high blood pressure and protein in the woman's urine, indicating kidney damage. It is one of the most serious reproductive conditions, posing substantial risks to the baby and potentially fatal for the mother. The causes of preeclampsia are largely unknown and environmental contaminants merit further investigation. The aim of this review was to determine the association between environmental chemical exposures and preeclampsia. PubMed was searched for articles examining a priori chemical exposures and preeclampsia through April 2018. Studies were included in our review if they included at least 10 cases, evaluated preeclampsia independent of gestational hypertension, and used either measured or modeled exposure assessments. Our review contained 28 investigations examining persistent organic pollutants (POP) (6 studies), drinking water contaminants (1 study), atmospheric pollutants (11 studies), metals and metalloids (6 studies), and other environmental contaminants (4 studies). There were an insufficient number of investigations on most chemicals to draw definitive conclusions, but strong evidence existed for an association between preeclampsia and cadmium (Cd). There is suggestive evidence for associations between nitrogen dioxide (NO

Indexed as

Environmental ExposureEnvironmental MonitoringEnvironmental PollutantsFemaleHumansIncidencePre-EclampsiaPregnancyEnvironmental Pollutantsenvironmental exposuresmaternal healthPreeclampsia

Identifiers

PMID30582407
PMCPMC6374047
OpenAlexW2906599930

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.