Evidence map›Paper›PMID 30582251›Full record

ArticleJournal of magnetic resonance imaging : JMRI2019

Combined 5-minute double-echo in steady-state with separated echoes and 2-minute proton-density-weighted 2D FSE sequence for comprehensive whole-joint knee MRI assessment.

Akshay S Chaudhari, Kathryn J Stevens, Bragi Sveinsson, Jeff P Wood, Christopher F Beaulieu, Edwin H G Oei, Jarrett K Rosenberg, Feliks Kogan, Marcus T Alley, Garry E Gold and 1 more

Abstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. RadCLIP: Enhancing Radiologic Image Analysis Through Contrastive Language-Image Pretraining.IEEE transactions on neural networks and learning systems · 2025
    Article
  5. Article
  6. Article
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  8. Article
  9. Review
  10. Magma (New York, N.Y.) · 2023
    Article
  11. Article
  12. A method for measuring BMagnetic resonance in medicine · 2023
    Article
  13. Imaging of Synovial Inflammation in Osteoarthritis, From theAJR. American journal of roentgenology · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Akshay S ChaudhariDepartment of Radiology, Stanford University, Stanford, California, USA.ORCID 0000-0002-3667-6796
Kathryn J StevensDepartment of Radiology, Stanford University, Stanford, California, USA.
Bragi SveinssonDepartment of Radiology, Stanford University, Stanford, California, USA.
Jeff P WoodDepartment of Radiology, Stanford University, Stanford, California, USA.
Christopher F BeaulieuDepartment of Radiology, Stanford University, Stanford, California, USA.
Edwin H G OeiDepartment of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Jarrett K RosenbergDepartment of Radiology, Stanford University, Stanford, California, USA.
Feliks KoganDepartment of Radiology, Stanford University, Stanford, California, USA.
Marcus T AlleyDepartment of Radiology, Stanford University, Stanford, California, USA.
Garry E GoldDepartment of Radiology, Stanford University, Stanford, California, USA.
Brian A HargreavesDepartment of Radiology, Stanford University, Stanford, California, USA.

Funding

Training and DisseminationP41EB015891 · NIBIB · STANFORD UNIVERSITY · PI GLOVER, GARY H · 2012 to 2019
$10.7M
Rapid MRI for Evaluation of OsteoarthritisR01EB002524 · NIBIB · STANFORD UNIVERSITY · PI Akshay Chaudhari, Garry E Gold · 2003 to 2026
$10.1M
Quantitative 3D Diffusion and Relaxometry MRI of the KneeR01AR063643 · NIAMS · STANFORD UNIVERSITY · PI HARGREAVES, BRIAN ANDREW · 2013 to 2017
$2.5M
Advanced MR Imaging of Early OsteoarthritisK24AR062068 · NIAMS · STANFORD UNIVERSITY · PI GOLD, GARRY E · 2012 to 2022
$1.7M
National Institutes of Health (NIH) NIH R01 AR063643NIAMS NIH HHS K24 AR062068NIAMS NIH HHS R01 AR063643NIBIB NIH HHS P41 EB015891NIBIB NIH HHS R01 EB002524
6 · The paper itself

Abstract

backgroundClinical knee MRI protocols require upwards of 15 minutes of scan time. PURPOSE/HYPOTHESIS: To compare the imaging appearance of knee abnormalities depicted with a 5-minute 3D double-echo in steady-state (DESS) sequence with separate echo images, with that of a routine clinical knee MRI protocol. A secondary goal was to compare the imaging appearance of knee abnormalities depicted with 5-minute DESS paired with a 2-minute coronal proton-density fat-saturated (PDFS) sequence. STUDY TYPE: Prospective. SUBJECTS: Thirty-six consecutive patients (19 male) referred for a routine knee MRI. FIELD STRENGTH/SEQUENCES: DESS and PDFS at 3T. ASSESSMENT: Five musculoskeletal radiologists evaluated all images for the presence of internal knee derangement using DESS, DESS+PDFS, and the conventional imaging protocol, and their associated diagnostic confidence of the reading. STATISTICAL TESTS: Differences in positive and negative percent agreement (PPA and NPA, respectively) and 95% confidence intervals (CIs) for DESS and DESS+PDFS compared with the conventional protocol were calculated and tested using exact McNemar tests. The percentage of observations where DESS or DESS+PDFS had equivalent confidence ratings to DESS+Conv were tested with exact symmetry tests. Interreader agreement was calculated using Krippendorff's alpha.

resultsDESS had a PPA of 90% (88-92% CI) and NPA of 99% (99-99% CI). DESS+PDFS had increased PPA of 99% (95-99% CI) and NPA of 100% (99-100% CI) compared with DESS (both P < 0.001). DESS had equivalent diagnostic confidence to DESS+Conv in 94% of findings, whereas DESS+PDFS had equivalent diagnostic confidence in 99% of findings (both P < 0.001). All readers had moderate concordance for all three protocols (Krippendorff's alpha 47-48%). DATA

conclusionBoth 1) 5-minute 3D-DESS with separated echoes and 2) 5-minute 3D-DESS paired with a 2-minute coronal PDFS sequence depicted knee abnormalities similarly to a routine clinical knee MRI protocol, which may be a promising technique for abbreviated knee MRI. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.

Indexed as

Magnetic Resonance ImagingAdipose TissueAdultAgedAlgorithmsFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedImaging, Three-DimensionalKneeKnee JointMaleMiddle AgedProspective StudiesProtonsabbreviated protocolDESSfast imagingknee MRIquantitative imaging

Identifiers

PMID30582251
PMCPMC7850298

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.