ArticleGeneral psychiatry2018
Microglia activation in the offspring of prenatal Poly I: C exposed rats: a PET imaging and immunohistochemistry study.
Article in General psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Comparison of Molecular Methods and BRAF Immunohistochemistry (VE1 Clone) for the Detection of BRAF V600E Mutation in Papillary Thyroid Carcinoma: A Meta-Analysis.Head and neck pathology · 2020Pooled it
- Multimodal neuroimaging alterations in schizophrenia model rats and the modulatory effects of risperidone: a pilot study.Frontiers in psychiatry · 2026Article
- Transient CSF1R inhibition ameliorates behavioral deficits in Cntnap2 knockout and valproic acid-exposed mouse models of autism.Journal of neuroinflammation · 2024Article
- Inhibition of NKCC1 Ameliorates Anxiety and Autistic Behaviors Induced by Maternal Immune Activation in Mice.Current issues in molecular biology · 2024Article
- Prenatal infection and adolescent social adversity affect microglia, synaptic density, and behavior in male rats.Neurobiology of stress · 2023Article
- Supplement Treatment with NAC and Omega-3 Polyunsaturated Fatty Acids during Pregnancy Partially Prevents Schizophrenia-Related Outcomes in the Poly I:C Rat Model.Antioxidants (Basel, Switzerland) · 2023Article
- Microglia sequelae: brain signature of innate immunity in schizophrenia.Translational psychiatry · 2022Review
- Unraveling the role of Epac1-SOCS3 signaling in the development of neonatal-CRD-induced visceral hypersensitivity in rats.CNS neuroscience & therapeutics · 2022Article
- Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits.Science advances · 2022Article
- Estrogen augmented visceral pain and colonic neuron modulation in a double-hit model of prenatal and adult stress.World journal of gastroenterology · 2021Article
- PAID study design on the role of PKC activation in immune/inflammation-related depression: a randomised placebo-controlled trial protocol.General psychiatry · 2021Article
- The Role of Butyric Acid in Treatment Response in Drug-Naïve First Episode Schizophrenia.Frontiers in psychiatry · 2021Article
- Maternal Immunity in Autism Spectrum Disorders: Questions of Causality, Validity, and Specificity.Journal of clinical medicine · 2020Review
- Bulleyaconitine A Inhibits Visceral Nociception and Spinal Synaptic Plasticity through Stimulation of Microglial Release of Dynorphin A.Neural plasticity · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe well-known 'pyrotherapy' of Julius Wagner-Jauregg might be the beginning of the study on the immunological concepts of schizophrenia. As the primary immune effector cells in the brain, microglia play a pivotal role in neuroinflammatory processes. Maternal viral infection during pregnancy is associated with an increased risk for psychiatric disorders with presumed neurodevelopmental origin, including autism spectrum disorders and schizophrenia. The present study was to quantify microglia activation in vivo in the mature offspring of rats exposed to polyriboinosinic-polyribocytidilicacid (Poly I:C) during pregnancy using
objectiveThe study aimed to quantify microglia activation in vivo in the prefrontal cortex and hippocampus in mature offspring of prenatal Poly I:C exposed rats.
methodsOffspring of Poly I:C-treated dams were the model group, offspring of saline-treated dams were the control group. Behavioural test for two groups was taken by spontaneous activity, prepulse inhibition (PPI) and latent inhibition (LI) test (including active avoidance conditioning task and passive avoidance conditioning task). Randomly selected successful model rats were assessed by behavioural test in the model group and control group rats.
resultsThe treatment group showed hyperlocomotion and deficits in PPI and LI compared with the control group. The treatment group also showed an increased
conclusionsThe present study demonstrated microglia activation in vivo in the prefrontal cortex and hippocampus in mature offspring of prenatal Poly I:C exposed rats. This study suggests that microglia activation may play a possible or potential role in the pathogenesis of schizophrenia.
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