ReviewBioactive materials2019
Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials.
Review in Bioactive materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 71 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it, 172 citations in OpenAlex.
- Clinical efficacy of bioactive restorative materials in controlling secondary caries: a systematic review and network meta-analysis.BMC oral health · 2023Pooled it
- Four-day plaque regrowth evaluation of a peptide chewing gum in a double-blind randomized clinical trial.Clinical and experimental dental research · 2020Trial
- Effect of incorporating calcium polyphosphate submicroparticles into bleaching gels on enamel surface loss after erosive challenge.Odontology · 2026Article
- Prevalence and associated factors of oral frailty in elderly patients undergoing elective surgery: a secondary analysis of a cross-sectional study.Frontiers in medicine · 2026Article
- Effect of different scaling instruments on the roughness of esthetic resin composite restorations: anFrontiers in dental medicine · 2026Article
- Effectiveness of CPP-ACP and fluoridated toothpastes in preserving enamel microhardness after erosion and abrasion challenges at different time intervals.BMC oral health · 2025Article
- Multimodal and Advanced Characterization of Dental Resin Composites: Insights into Beverage-Induced Degradation.Journal of clinical medicine · 2025Article
- Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries.Medical review (2021) · 2025Review
- Impact of solutions and storage time on the chemical and mechanical properties of human dentin.Journal of clinical and experimental dentistry · 2025Article
- The impact of dimethylaminohexadecyl methacrylates on the physical and antibacterial properties of endodontic sealers.Frontiers in oral health · 2025Article
- Novel antimicrobial and bioactive resin-based clear aligner attachment orthodontic materials.Frontiers in oral health · 2025Article
- Recent Achievements and Perspectives in Smart Nano-in-Micro Platforms for Ocular Disease Treatment.International journal of nanomedicine · 2025Review
- The impact ofFrontiers in dental medicine · 2025Article
- Nanocarriers and Nanomaterials in Dentistry: A Review on Common Dental Issues and their Management.Current pharmaceutical design · 2025Review
- Effect of Different Pediatric Medications on RMGIC: A Comparative Study.Journal of pharmacy & bioallied sciences · 2024Article
- A review of new generation of dental restorative resin composites with antibacterial, remineralizing and self-healing capabilities.Discover nano · 2024Review
- Polymer vesicles for the delivery of inhibitors of cariogenic biofilm.Dental materials : official publication of the Academy of Dental Materials · 2024Article
- Effect of Stearyl Methacrylate Comonomer on the Mechanical and Physical Properties of Dimethacrylate-Based Dental Resins.Materials (Basel, Switzerland) · 2024Article
- Effect of incorporation of calcium polyphosphate sub-microparticles in low-concentration bleaching gels on physical properties of dental enamel.Odontology · 2024Article
- Clinical Effectiveness of Ion-Releasing Restorations versus Composite Restorations in Dental Restorations: Systematic Review and Meta-Analysis.Dentistry journal · 2024Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Millions of people worldwide suffer from a toothache due to tooth cavity, and often permanent tooth loss. Dental caries, also known as tooth decay, is a biofilm-dependent infectious disease that damages teeth by minerals loss and presents a high incidence of clinical restorative polymeric fillings (tooth colored fillings). Until now, restorative polymeric fillings present no bioactivity. The complexity of oral biofilms contributes to the difficulty in developing effective novel dental materials. Nanotechnology has been explored in the development of bioactive dental materials to reduce or modulate the activities of caries-related bacteria. Nano-structured platforms based on calcium phosphate and metallic particles have advanced to impart an anti-caries potential to restorative materials. The bioactivity of these platforms induces prevention of mineral loss of the hard tooth structure and antibacterial activities against carries-related pathogens. It has been suggested that this bioactivity could minimize the incidence of caries around restorations (CARS) and increase the longevity of such filling materials. The last few years witnessed growing numbers of studies on the preparation evaluations of these novel materials. Herein, the caries disease process and the role of pathogenic caries-related biofilm, the increasing incidence of CARS, and the recent efforts employed for incorporation of bioactive nanoparticles in restorative polymer materials as useful strategies for prevention and management of caries-related-bacteria are discussed. We highlight the status of the most advanced and widely explored interaction of nanoparticle-based platforms and calcium phosphate compounds with an eye toward translating the potential of these approaches to the dental clinical reality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.