ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019
White matter and its relationship with cognition in subjective cognitive decline.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 56 citations in OpenAlex.
- Digital twins support cross-modal and cross-centric classification of mild cognitive impairment.Communications medicine · 2026Article
- Clinical definition, biological characterization, and detection guidelines of subjective cognitive decline due to Alzheimer's disease and related dementia: A position paper from ISTAART SCD PIA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Long-term neurobehavioral and neuroimaging outcomes in athletes with prior concussion(s) and head impact exposure.The Clinical neuropsychologist · 2025Review
- Digital twins and non-invasive recordings enable early diagnosis of Alzheimer's disease.Alzheimer's research & therapy · 2025Observational
- Body mass index changes and trajectories from midlife to late-life: association with subjective cognitive complaints in a 30-year Women's cohort study.Age and ageing · 2025Article
- Personalized brain models link cognitive decline progression to underlying synaptic and connectivity degeneration.Alzheimer's research & therapy · 2025Article
- Observational
- Attention and spatial navigation in everyday life: Physical activity is associated with subjective aspects of cognitive function.PloS one · 2025Article
- Advances in the use of structural and diffusion magnetic resonance imaging for characterizing SCD and MCI due to Alzheimer's disease.Frontiers in neuroscience · 2025Review
- Study on the age-period-cohort effects of cognitive abilities among older Chinese adults based on the cognitive reserve hypothesis.BMC geriatrics · 2024Article
- Brain structure, amyloid, and behavioral features for predicting clinical progression in subjective cognitive decline.Human brain mapping · 2024Article
- More organized white matter is associated with positivity bias in older adults.Brain imaging and behavior · 2024Article
- White matter alterations and their associations with biomarkers and behavior in subjective cognitive decline individuals: a fixel-based analysis.Behavioral and brain functions : BBF · 2024Article
- Non-invasive neuromodulation of cerebello-hippocampal volume-behavior relationships.bioRxiv : the preprint server for biology · 2024Article
- The potential of blood neurofilament light as a marker of neurodegeneration for Alzheimer's disease.Brain : a journal of neurology · 2024Review
- Feasibility and reliability of online vs in-person cognitive testing in healthy older people.PloS one · 2024Article
- Diffusion imaging markers of accelerated aging of the lower cingulum in subjective cognitive decline.Frontiers in neurology · 2024Article
- Changes in Multiparametric Magnetic Resonance Imaging and Plasma Amyloid-Beta Protein in Subjective Cognitive Decline.Brain sciences · 2023Article
- Investigating the association between subjective and objective performance-based cognitive function among former collegiate football players.The Clinical neuropsychologist · 2023Article
- N-acetyl-aspartate and Myo-inositol as Markers of White Matter Microstructural Organization in Mild Cognitive Impairment: Evidence from a DTI-Diagnostics (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
introductionSubjective cognitive decline (SCD) is the earliest stage on the continuum toward Alzheimer's disease. This study examined (1) differences in white matter integrity between individuals with SCD and healthy control subjects and (2) how white matter integrity related to memory and executive function.
methodsDiffusion tensor imaging and neuropsychological assessment data were retrieved from the Alzheimer's Disease Neuroimaging Initiative database for 30 individuals with SCD and 44 control subjects.
resultsResults revealed significantly lower white matter integrity in individuals with SCD relative to control subjects in widespread regions, including the bilateral corticospinal tracts, superior and inferior longitudinal fasciculi, fronto-occipital fasciculi, corpus callosum, forceps major and minor, hippocampi, anterior thalamic radiations, and the cerebellum. There was a widespread relationship between diffusion tensor imaging metrics and executive function in SCD, but not healthy control subjects, and no relationship with memory for either group. DISCUSSION: Relatively lower white matter integrity in SCD may be a useful early biomarker for risk of future cognitive decline. Future research should better characterize the SCD group longitudinally and in individuals at risk for Alzheimer's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.