ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019
Retinal ganglion cell-inner plexiform layer thickness is nonlinearly associated with cognitive impairment in the community-dwelling elderly.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Multimodal Retinal Imaging for the Detection of Early Alzheimer's Disease: Combining Biochemical, Structural, and Vascular Biomarkers.Bioengineering (Basel, Switzerland) · 2026Article
- Photoreceptor Layer Thinning as Biomarker for Circulatory Premature Mortality: UK Biobank Cohort Study.Translational vision science & technology · 2025Article
- Retinochoroidal and Optic Nerve Head Microstructural and Microvascular Age-Related Changes in Healthy Eyes.Diagnostics (Basel, Switzerland) · 2025Article
- Retinal nerve fibre layer thickness is associated with attention and predicts risk states of dementia.Brain communications · 2025Article
- Eye-brain connections revealed by multimodal retinal and brain imaging genetics.Nature communications · 2024Article
- Association of retinal optical coherence tomography metrics and polygenic risk scores with cognitive function and future cognitive decline.The British journal of ophthalmology · 2024Article
- Cohort profile: the Taiwan Initiative for Geriatric Epidemiological Research - a prospective cohort study on cognition.Epidemiology and health · 2024Article
- Retinal biomarkers for the risk of Alzheimer's disease and frontotemporal dementia.Frontiers in aging neuroscience · 2024Article
- Eye-brain connections revealed by multimodal retinal and brain imaging genetics in the UK Biobank.medRxiv : the preprint server for health sciences · 2023Article
- Longitudinal Analysis of the Retina and Choroid in Cognitively Normal Individuals at Higher Genetic Risk of Alzheimer Disease.Ophthalmology. Retina · 2022Article
- Retinal ganglion cell layer thickness and volume measured by OCT changes with age, sex, and axial length in a healthy population.BMC ophthalmology · 2022Article
- Schizophrenia in Translation: Why the Eye?Schizophrenia bulletin · 2022Article
- Association of retinal thickness and microvasculature with cognitive performance and brain volumes in elderly adults.Frontiers in aging neuroscience · 2022Article
- Visual deficits and cognitive assessment of multiple sclerosis: confounder, correlate, or both?Journal of neurology · 2021Article
- Ganglion cell layer thickening in patients suffering from Obstructive Sleep Apnea-Hypopnea syndrome with long Mean Apnea-Hypopnea Duration during sleep.International ophthalmology · 2021Article
- Individuals with and without normal tension glaucoma exhibit comparable performance on tests of cognitive function.International journal of ophthalmology · 2021Article
- Retinal imaging in Alzheimer's and neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Review
- Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer's disease.Acta neuropathologica communications · 2020Article
- Macular Ganglion Cell-Inner Plexiform Layer as a Marker of Cognitive and Sensory Function in Midlife.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- A recommended "minimum data set" framework for SD-OCT retinal image acquisition and analysis from the Atlas of Retinal Imaging in Alzheimer's Study (ARIAS).Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThinning of optical coherence tomography-measured retinal nerve fiber layer thickness and ganglion cell-inner plexiform layer (GC-IPL) thickness has been found in patients with Alzheimer's disease. However, the association of these retinal markers and cognition in nondemented elders may not be linear.
methodsThis cross-sectional study included 227 community-dwelling elders (age 65+ years). Multivariable regression analyses were performed to investigate the association between retinal nerve fiber layer/GC-IPL and global/domain-specific cognition.
resultsThe performance of global cognition decreased as mean GC-IPL of bilateral eyes deviated from the sample mean (77.5 μm) (quadratic GC-IPL: β = -0.49 × 10 DISCUSSION: Either thinning or thickening of GC-IPL was associated with poor cognition in nondemented elderly (a U-shaped association). GC-IPL may serve as a noninvasive preclinical predictor of Alzheimer's disease.
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