Evidence map›Paper›PMID 30581896›Full record

ArticleRegenerative therapy2019

Endoscopic repair of the urinary bladder with magnetically labeled mesenchymal stem cells: Preliminary report.

Kosuke Sadahide, Jun Teishima, Shogo Inoue, Takayuki Tamura, Naosuke Kamei, Nobuo Adachi, Akio Matsubara

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kosuke SadahideDepartment of Urology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Jun TeishimaDepartment of Urology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Shogo InoueDepartment of Urology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Takayuki TamuraDepartment of Radiology, Hiroshima University Hospital, Hiroshima, Japan.
Naosuke KameiDepartment of Orthopaedic Surgery, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Nobuo AdachiDepartment of Orthopaedic Surgery, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Akio MatsubaraDepartment of Urology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Hiroshima University · JPHiroshima University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTransurethral resection of a bladder tumor (TURBT) using a resectoscope has been standard treatment for bladder cancer. However, no treatment method promotes the repair of resected bladder tissue. The aim of this study was to examine the healing process of damaged bladder tissue after a transurethral injection of bone marrow mesenchymal stem cells (MSCs) into the bladder. An injection of magnetic MSCs meant that they accumulated in the damaged area of the bladder. Another aim of this study was to compare the acceleration effect of MSC magnetic delivery on the repair of bladder tissue with that of non-magnetic MSC injection.

methodsUsing the transurethral approach to avoid opening the abdomen, electrofulguration was carried out on the anterior wall of the urinary bladder of white Japanese rabbits to mimic tumor resection. An external magnetic field directed at the injured site was then applied using a 1-tesla (T) permanent magnet. Twelve rabbits were divided into three groups. The 1 × 10

resultsThe macroscopic findings showed the area of repair tissue in the MSC M+ group to be larger than that in either the MSC M-group or control group. MRI clearly depicted the macroscopic findings. The histological study showed that repair of the cauterized area with myofibrous tissue was significantly better in the MSC M+ group than that in either the MSC M-group or control group, although there was no significant difference in several mRNA cytokines among the three groups at 14 days after surgery.

conclusionsThe magnetic delivery of MSCs shows promise as an effective, minimally invasive method of enhancing tissue regeneration after TURBT.

Indexed as

BC, urinary bladder cancerBone marrowCancerFA, flip angleFBS, fetal bovine serumH&E, hematoxylin and eosinMesenchymal stem cellMRI, Magnetic resonance imagingMSC, mesenchymal stem cellNEX, number of excitationsNMIBC, non-muscle invasive urinary bladder cancerPBS, phosphate-buffered salinePCR, polymerase chain reactionRegenerationSPION, superparamagnetic iron oxide nanoparticleTE, echo timeTransurethral resectionTR, repetition timeTURBT, transurethral resection of bladder tumorUrinary bladderαSMA, α-smooth muscle actin

Identifiers

PMID30581896
PMCPMC6299148
OpenAlexW2905049294

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.