Evidence map›Paper›PMID 30581881›Full record

ArticleOpen forum infectious diseases2018

Plasma Cell-Free DNA Next-Generation Sequencing to Diagnose and Monitor Infections in Allogeneic Hematopoietic Stem Cell Transplant Patients.

Monica Fung, Simona Zompi, Hon Seng, Desiree Hollemon, Adama Parham, David K Hong, Sivan Bercovici, Estelle Dolan, Kathy Lien, Justin Teraoka and 2 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Impact of direct from clinical sample sequencing assays for infectious diseases diagnostics: A single-centre retrospective cohort study.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2026
    Article
  3. Critical Steps in Shotgun Metagenomics-Based Diagnosis of Bloodstream Infections Using Nanopore Sequencing.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2025
    Article
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  12. Rapid, Noninvasive Diagnosis ofOpen forum infectious diseases · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Monica FungDivision of Infectious Diseases, University of California San Francisco, San Francisco, California.
Simona ZompiKarius, Inc., Redwood City, California.
Hon SengKarius, Inc., Redwood City, California.
Desiree HollemonKarius, Inc., Redwood City, California.
Adama ParhamKarius, Inc., Redwood City, California.
David K HongKarius, Inc., Redwood City, California.
Sivan BercoviciKarius, Inc., Redwood City, California.
Estelle DolanSchool of Medicine, University of California Davis, Sacramento, California.
Kathy LienDivision of Infectious Diseases, University of California San Francisco, San Francisco, California.
Justin TeraokaDivision of Infectious Diseases, University of California San Francisco, San Francisco, California.
Aaron C LoganDivision of Hematology and Blood and Marrow Transplantation, University of California San Francisco, San Francisco, California.
Peter Chin-HongDivision of Infectious Diseases, University of California San Francisco, San Francisco, California.

Funding

BIOLOGY OF INFECTIOUS DISEASES TRAINING PROGRAMT32AI007641 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY · 2000 to 2026
$6.9M
NIAID NIH HHS T32 AI007641
6 · The paper itself

Abstract

Allogeneic hematopoietic stem cell transplant patients are at risk for common and atypical infections. Superior diagnostics can decrease infection-related morbidity and mortality. A novel plasma cell-free DNA next-generation sequencing test detected an uncommon presentation of

Indexed as

immunocompromisedmolecular diagnosticsnext-generation sequencingstem cell transplant

Identifiers

PMID30581881
PMCPMC6297859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.