ArticleAnnals of translational medicine2018
Impact of subglottic secretion drainage on microaspiration in critically ill patients: a prospective observational study.
Article in Annals of translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- The efficacy of subglottic secretion drainage in preventing ventilator-associated pneumonia in the intensive care unit: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Value of bronchial amylase level for predicting ventilator associated pneumonia in intubated adults: a systematic review and meta-analysis.BMC pulmonary medicine · 2024Pooled it
- Intubation Setting, Aspiration, and Ventilator-Associated Conditions.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2020Trial
- Impact of deep oropharyngeal suctioning on microaspiration, ventilator events, and clinical outcomes: A randomized clinical trial.Journal of advanced nursing · 2019Trial
- Strategies to prevent ventilator-associated pneumonia in critically ill mechanically ventilated patients: a SIAARTI consensus statement.Journal of anesthesia, analgesia and critical care · 2026Review
- Effect of humidification intervention combined with cluster nursing on ventilator-associated pneumonia in ICU patients.Frontiers in public health · 2025Observational
- Is COPD associated with increased risk for microaspiration in intubated critically ill patients?Annals of intensive care · 2021Article
- Transesophageal echocardiography-associated tracheal microaspiration and ventilator-associated pneumonia in intubated critically ill patients: a multicenter prospective observational study.Critical care (London, England) · 2020Observational
- Is α-Amylase an Important Biomarker to Detect Aspiration of Oral Secretions in Ventilated Patients?Critical care explorations · 2020Article
- Pathogenesis-Targeted Preventive Strategies for Multidrug Resistant Ventilator-Associated Pneumonia: A Narrative Review.Microorganisms · 2020Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroaspiration is a major factor in ventilator-associated pneumonia (VAP) pathophysiology. Subglottic secretion drainage (SSD) aims at reducing its incidence.
methodsSingle-center prospective observational study, performed in a French intensive care unit (ICU) from March 2012 to April 2013, including adult patients mechanically ventilated for at least 24 hours divided in two groups: patients in the SSD group intubated using tracheal tubes allowing SSD and patients in the control group intubated with standard tracheal tubes. Pepsin and salivary amylase concentrations were measured for 24 hours in all tracheal aspirates. Primary objective was to determine the impact of SSD on gastric or oropharyngeal microaspiration using pepsin or amylase concentration in tracheal aspirates.
resultsFifty-five patients were included in the SSD group and 45 in the control group. No difference was found between groups regarding the incidence of microaspiration defined as at least one tracheal aspirate positive for either pepsin or amylase [49 (89%)
conclusionsSSD did not reduce the incidence of microaspiration, VAP, VAT or airway colonization in this observational study.
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