ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2018
Bio-Inspired Micropatterned Platforms Recapitulate 3D Physiological Morphologies of Bone and Dentinal Cells.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Unraveling novel insights into dual-species cariogenic biofilm formation on aged teeth: a comparative analysis on natural vs artificial bioengineered dentin models.Applied and environmental microbiology · 2025Article
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- Dentin Mechanobiology: Bridging the Gap between Architecture and Function.International journal of molecular sciences · 2024Review
- Hydrogel armed with Bmp2 mRNA-enriched exosomes enhances bone regeneration.Journal of nanobiotechnology · 2023Article
- High-Throughput Dispensing of Viscous Solutions for Biomedical Applications.Micromachines · 2022Article
- Biomimetic Tubular Matrix Induces Periodontal Ligament Principal Fiber Formation and Inhibits Osteogenic Differentiation of Periodontal Ligament Stem Cells.ACS applied materials & interfaces · 2022Article
- Osteon: Structure, Turnover, and Regeneration.Tissue engineering. Part B, Reviews · 2022Review
- Research progress on the biological modifications of implant materials in 3D printed intervertebral fusion cages.Journal of materials science. Materials in medicine · 2021Review
- Dental Pulp Stem Cell Polarization: Effects of Biophysical Factors.Journal of dental research · 2021Article
- Nanofibrous Tubular Three-Dimensional Platform for Single Dental Pulp Stem Cell Polarization.ACS applied materials & interfaces · 2020Article
- Converting 2D Nanofiber Membranes to 3D Hierarchical Assemblies with Structural and Compositional Gradients Regulates Cell Behavior.Advanced materials (Deerfield Beach, Fla.) · 2020Article
- ECM-mimicking nanofibrous matrix coaxes macrophages toward an anti-inflammatory phenotype: Cellular behaviors and transcriptome analysis.Applied materials today · 2020Article
- Locally Controlled Diffusive Release of Bone Morphogenetic Protein-2 Using Micropatterned Gelatin Methacrylate Hydrogel Carriers.Biochip journal · 2020Article
- Cell polarization: From epithelial cells to odontoblasts.European journal of cell biology · 2019Review
- Bio-Inspired Micropatterned Platforms Recapitulate 3D Physiological Morphologies of Bone and Dentinal Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cells exhibit distinct 3D morphologies in vivo, and recapitulation of physiological cell morphologies in vitro is pivotal not only to elucidate many fundamental biological questions, but also to develop new approaches for tissue regeneration and drug screening. However, conventional cell culture methods in either a 2D petri dish or a 3D scaffold often lead to the loss of the physiological morphologies for many cells, such as bone cells (osteocytes) and dentinal cells (odontoblasts). Herein, a unique approach in developing a 3D extracellular matrix (ECM)-like micropatterned synthetic matrix as a physiologically relevant 3D platform is reported to recapitulate the morphologies of osteocytes and odontoblasts in vitro. The bio-inspired micropatterned matrix precisely mimics the hierarchic 3D nanofibrous tubular/canaliculi architecture as well as the compositions of the ECM of mineralized tissues, and is capable of controlling one single cell in a microisland of the matrix. Using this bio-inspired 3D platform, individual bone and dental stem cells are successfully manipulated to recapitulate the physiological morphologies of osteocytes and odontoblasts in vitro, respectively. This work provides an excellent platform for an in-depth understanding of cell-matrix interactions in 3D environments, paving the way for designing next-generation biomaterials for tissue regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.