ArticleFrontiers in immunology2018
Bactericidal/Permeability-Increasing Protein Is an Enhancer of Bacterial Lipoprotein Recognition.
Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Aquatic BPI/LBPs: A Promising Antimicrobial Peptide Resource for Disease Control in Aquaculture.Current protein & peptide science · 2026Review
- Bactericidal Permeability-Increasing Protein (BPI) InhibitsBiomolecules · 2024Article
- Subversion of a family of antimicrobial proteins byFrontiers in cellular and infection microbiology · 2024Article
- Unravelling mechanisms of bacterial recognition by Acanthamoeba: insights into microbial ecology and immune responses.Frontiers in microbiology · 2024Review
- Article
- Identification and Functional Analysis ofGenes · 2023Article
- Inflammasome activation by Gram-positive bacteria: Mechanisms of activation and regulation.Frontiers in immunology · 2023Review
- A Polymorphism of Bactericidal/Permeability-Increasing Protein Affects Its Neutralization Efficiency towards Lipopolysaccharide.International journal of molecular sciences · 2022Article
- Monocyte biology conserved across species: Functional insights from cattle.Frontiers in immunology · 2022Article
- The Reaction Pathway of miR-30c-5p Activates Lipopolysaccharide Promoting the Course of Traumatic and Hemorrhagic Shock Acute Lung Injury.BioMed research international · 2022Article
- Differential Enhancement of Neutrophil Phagocytosis by Anti-Bactericidal/Permeability-Increasing Protein Antibodies.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Identification of key candidate biomarkers for severe influenza infection by integrated bioinformatical analysis and initial clinical validation.Journal of cellular and molecular medicine · 2021Article
- Killing three birds with one BPI: Bactericidal, opsonic, and anti-inflammatory functions.Journal of translational autoimmunity · 2021Review
- Modulation of Host Immune Response duringFrontiers in immunology · 2021Article
- BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus.Theranostics · 2021Article
- Lipopolysaccharide Binding Protein and Bactericidal/Permeability-Increasing Protein as Biomarkers for Invasive Pulmonary Aspergillosis.Journal of fungi (Basel, Switzerland) · 2020Article
- Low-Avidity Autoantibodies against Bactericidal/Permeability-Increasing Protein Occur in Gram-Negative and Gram-Positive Bacteremia.Infection and immunity · 2020Article
- A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions.Cell · 2020Article
- Network Medicine Approach for Analysis of Alzheimer's Disease Gene Expression Data.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adequate perception of immunologically important pathogen-associated molecular patterns like lipopolysaccharide and bacterial lipoproteins is essential for efficient innate and adaptive immune responses. In the context of Gram-negative infection, bactericidal/permeability-increasing protein (BPI) neutralizes endotoxic activity of lipopolysaccharides, and thus prohibits hyperactivation. So far, no immunological function of BPI has been described in Gram-positive infections. Here, we show a significant elevation of BPI in Gram-positive meningitis and, surprisingly, a positive correlation between BPI and pro-inflammatory markers like TNFα. To clarify the underlying mechanisms, we identify BPI ligands of Gram-positive origin, specifically bacterial lipopeptides and lipoteichoic acids, and determine essential structural motifs for this interaction. Importantly, the interaction of BPI with these newly defined ligands significantly enhances the immune response in peripheral blood mononuclear cells (PBMCs) mediated by Gram-positive bacteria, and thereby ensures their sensitive perception. In conclusion, we define BPI as an immune enhancing pattern recognition molecule in Gram-positive infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.