ArticleJournal of medical biochemistry2017
The Monitoring of Protein Markers of Inflammation and Serum Lipid Concentration in Obese Subjects with Metabolic Syndrome.
Article in Journal of medical biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Regular collagen peptide administration exerts anti-obesity effects in high-caloric diet-fed rodents-a systematic review with meta-analysis of animal trials.International journal of obesity (2005) · 2026Pooled it
- Adipokine, endocrine, and fibrinolysis-related alterations across abdominal obesity and metabolic syndrome phenotypes in young adults.Frontiers in endocrinology · 2026Article
- Effect of Diet on HDL in Obesity.Molecules (Basel, Switzerland) · 2024Review
- Myeloperoxidase enzyme and Ferric-reducing antioxidant power concentrations in lean and obese dogs.Veterinary research communications · 2023Article
- Effects of 2-Year Nutritional and Lifestyle Intervention on Oxidative and Inflammatory Statuses in Individuals of 55 Years of Age and over at High Cardiovascular Risk.Antioxidants (Basel, Switzerland) · 2022Article
- High-fructose diet initially promotes increased aortic wall thickness, liver steatosis, and cardiac histopathology deterioration, but does not increase body fat index.Journal of public health research · 2021Article
- Association of MACROD2 gene variants with obesity and physical activity in a Korean population.Molecular genetics & genomic medicine · 2021Article
- Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes.Scientific reports · 2020Observational
- Metabolic Syndrome is Associated with Oxidative Stress and Proinflammatory State.Antioxidants (Basel, Switzerland) · 2020Article
- CD4/CD8 Ratio as a Predictor for the Occurrence of Metabolic Syndrome in HIV / AIDS Patients During 6 Months of cART Therapy.Journal of medical biochemistry · 2019Article
- Relationship Between Hematological Parameters and Glycemic Control in Type 2 Diabetes Mellitus Patients.Journal of medical biochemistry · 2019Article
- Association of FTO Gene Variant (rs8050136) with Type 2 Diabetes and Markers of Obesity, Glycaemic Control and Inflammation.Journal of medical biochemistry · 2019Article
- Undiagnosed Hyperglycaemia and Hypertension as Indicators of the Various Risk Factors of Future Cardiovascular Disease Among Population of Serbian Students.Journal of medical biochemistry · 2018Article
- Effects of Glucose Ingestion on Serum Fractalkine Levels in Healthy Subjects and Newly Diagnosed Type 2 Diabetic Patients.Journal of medical biochemistry · 2018Article
- Association between MTHFR 677C>T Polymorphism and Vitamin B12 Deficiency: A Case-control Study.Journal of medical biochemistry · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is one of the most common modern health problems worldwide. Proinflammatory cells accumulate in the adipose tissue of the obese, and the presence of a low level chronic inflammation in obesity is associated with the emergence of a range of metabolic disorders in cluding cardiovascular disease, insulin resistance, type-2 diabetes, fatty-liver disease, and others. Neutrophils are early parti - cipants in inflammatory processes. After the appropriate stimu lation, these cells release reactive oxygen and nitrogen species, which leads to degranulation and secretion of myeloperoxidase and other enzymes. Myelo per oxidase and its reactive oxidants contribute to tissue damage during inflammatory processes in the human body.
methodsThe study included 175 subjects who were, in com - pliance with the International Diabetes Federation criteria, divided into 3 groups: normal weight subjects (N=106), subjects with abdominal obesity (N=37) and the third group consisted of subjects with the metabolic syndrome (N=32).
resultsBy analyzing the myeloperoxidase enzyme activity (kU/L), and the levels of high-sensitivity C-reactive protein in the blood of all subjects, we detected their significantly higher activity and levels in subjects with the metabolic syndrome, as compared to normal weight subjects (p<0.001).
conclusionsBased on our results, we can conclude that the MPO activity in the serum progressively increases with obesity and the metabolic syndrome, which indicates that this prooxidant enzyme may play a role in the pathophysiological mechanisms of the obesity and the metabolic syndrome related complications.
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Registered trials
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