ReviewDialogues in clinical neuroscience2018
Forty years of structural brain imaging in mental disorders: is it clinically useful or not?
Review in Dialogues in clinical neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Systematic Review of Functional MRI Applications for Psychiatric Disease Subtyping.Frontiers in psychiatry · 2021Pooled it
- Association of sexual dysfunctions according to DSM-5 criteria with structural brain differences in women and men from the Hamburg City Health Study.Dialogues in clinical neuroscience · 2026Article
- Neuroimaging Data Informed Mood and Psychosis Diagnosis Using an Ensemble Deep Multimodal Framework.Human brain mapping · 2025Article
- Investigating cross-sectional and longitudinal relationships between brain structure and distinct dimensions of externalizing psychopathology in the ABCD sample.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Performance reserves in brain-imaging-based phenotype prediction.Cell reports · 2024Article
- A statistical method for image-mediated association studies discovers genes and pathways associated with four brain disorders.American journal of human genetics · 2024Article
- Challenges of implementing computer-aided diagnostic models for neuroimages in a clinical setting.NPJ digital medicine · 2023Review
- Adversarial confound regression and uncertainty measurements to classify heterogeneous clinical MRI in Mass General Brigham.PloS one · 2023Article
- Potential Inflammatory Biomarker in Patients with Attention Deficit Hyperactivity Disorder.International journal of molecular sciences · 2022Review
- Abnormal corneal nerve morphology and brain volume in patients with schizophrenia.Scientific reports · 2022Article
- Schizophrenia: A Survey of Artificial Intelligence Techniques Applied to Detection and Classification.International journal of environmental research and public health · 2021Review
- A Comprehensive Review of Computer-Aided Diagnosis of Major Mental and Neurological Disorders and Suicide: A Biostatistical Perspective on Data Mining.Diagnostics (Basel, Switzerland) · 2021Review
- Improving Between-Group Effect Size for Multi-Site Functional Connectivity Data via Site-Wise De-Meaning.Frontiers in computational neuroscience · 2021Article
- Fractures in the framework: limitations of classification systems in psychiatry .Dialogues in clinical neuroscience · 2020Review
- Are There Any Biomarkers for Pedophilia and Sexual Child Abuse? A Review.Frontiers in psychiatry · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Structural brain imaging was introduced into routine clinical practice more than 40 years ago with the hope that it would support the diagnosis and treatment of mental disorders. It is now widely used to exclude organic brain disease (eg, brain tumors, cardiovascular, and inflammatory processes) in mental disorders. However, questions have been raised about whether structural brain imaging is still needed today and whether it could also be clinically useful to apply new biostatistical methods, such as machine learning. Therefore, the current paper not only reviews structural findings in Alzheimer disease, depression, bipolar disorder, and schizophrenia but also discusses the role of structural imaging in supporting diagnostic, prognostic, and therapeutic processes in mental disorders. Thus, it attempts to answer the questions whether, after four decades of use, structural brain imaging is clinically useful in mental disorders or whether it will become so in the future.
Indexed as
Identifiers
30581287PMC6296397W2993581711What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.