Evidence map›Paper›PMID 30581234›Full record

ArticleThe journal of extra-corporeal technology2018

Role of Methadone in Extracorporeal Membrane Oxygenation: Two Case Reports.

Erik Dong, Robert Fellin, Danny Ramzy, Joshua S Chung, Francisco A Arabia, Alice Chan, David Ng, Nicola D'Attellis, Michael Nurok

Abstract readCase Reports
PubMed Full text at PMC
In one paragraph

Article in The journal of extra-corporeal technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Analgosedation in Critically Ill Adults Receiving Extracorporeal Membrane Oxygenation Support.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Erik DongCedars Sinai Medical Center, Los Angeles, California.
Robert FellinCedars Sinai Medical Center, Los Angeles, California.
Danny RamzyCedars Sinai Medical Center, Los Angeles, California.
Joshua S ChungCedars Sinai Medical Center, Los Angeles, California.
Francisco A ArabiaCedars Sinai Medical Center, Los Angeles, California.
Alice ChanCedars Sinai Medical Center, Los Angeles, California.
David NgCedars Sinai Medical Center, Los Angeles, California.
Nicola D'AttellisCedars Sinai Medical Center, Los Angeles, California.
Michael NurokCedars Sinai Medical Center, Los Angeles, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracorporeal membrane oxygenation (ECMO) affects pharmacokinetics/dynamics of drugs in unpredictable ways. Anecdotally, ECMO patients require high doses of opioids and sedatives, leading to concerns of tolerance. Methadone is a long-acting synthetic opioid with antagonist properties at the n-methyl-d-aspartate (NMDA) receptor. It has been shown to improve spontaneous breathing trials and weaning from mechanical ventilation; however, there is no literature describing its use in ECMO. We describe two patients from the cardiac surgery intensive care unit at Cedars Sinai (Los Angeles, CA) on ECMO for over 30 days maintained on methadone.

Indexed as

Extracorporeal Membrane OxygenationAnalgesics, OpioidHumansHypnotics and SedativesMethadoneVentilator WeaningAnalgesics, OpioidHypnotics and SedativesMethadoneanalgesicscritical careextracorporeal membrane oxygenationmethadonesedation

Identifiers

PMID30581234
PMCPMC6296449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.