Evidence map›Paper›PMID 30581228›Full record

ArticleThe journal of extra-corporeal technology2018

Impact of Hemolysis on Acute Kidney Injury and Mortality in Children Supported with Cardiac Extracorporeal Membrane Oxygenation.

Santiago Borasino, Yuvraj Kalra, Ashley R Elam, Lawrence Carlisle O'Meara, Joseph G Timpa, Kellen G Goldberg, J Leslie Collins Gaddis, Jeffrey A Alten

Abstract read
In one paragraph

Article in The journal of extra-corporeal technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Severe cholestasis in neonatal extracorporeal membrane oxygenation.The journal of extra-corporeal technology · 2025
    Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Acute Kidney Injury and Extracorporeal Membrane Oxygenation: Review on Multiple Organ Support Options.International journal of nephrology and renovascular disease · 2021
    Review
  12. Article
  13. Article
  14. Device-Induced Hemostatic Disorders in Mechanically Assisted Circulation.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Santiago BorasinoDepartment of Pediatric Cardiology, Section of Cardiac Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Yuvraj KalraDepartment of Pediatric Cardiology, Section of Cardiac Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Ashley R ElamDepartments of Internal Medicine and Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.
Lawrence Carlisle O'MearaCardiovascular Perfusion, Children's of Alabama, Birmingham, Alabama.
Joseph G TimpaCardiovascular Perfusion, Children's of Alabama, Birmingham, Alabama.
Kellen G GoldbergCardiovascular Perfusion, Children's of Alabama, Birmingham, Alabama.
J Leslie Collins GaddisDepartment of Pediatric Cardiology, University of Alabama at Birmingham, Birmingham, Alabama.
Jeffrey A AltenDepartment of Pediatrics, Section of Cardiology, University of Cincinnati College of Medicine, Cincinnati, Ohio; and.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intravascular hemolysis with elevated plasma-free hemoglobin (PFH) complicates extracorporeal membrane oxygenation (ECMO). In 50 consecutive pediatric cardiac patients requiring ECMO, we sought to describe the relationship between PFH and clinical outcomes; primary outcomes were acute kidney injury (AKI) and prolonged (>14 days) renal replacement therapy (RRT). Median age was 35 days, median weight 3.9 kg, and median ECMO duration 4.2 days. Seventy-eight percent (39/50) weaned off ECMO; survival to discharge was 50% (25/50). Seventy percent (35/50) had AKI on ECMO. Seventy-seven percent (30/39) required RRT post-ECMO; median duration was 5.2 days (0, 14.2). Prolonged RRT was associated with higher daily PFH (67.5 mg/dL [54.1, 102.5] vs. 46.7 mg/dL [40, 72.6],

Indexed as

Acute Kidney InjuryExtracorporeal Membrane OxygenationHemolysisHumansInfantInfant, NewbornRenal Replacement TherapyRetrospective StudiesTreatment Outcomeacute kidney injurycardiac extracorporeal membrane oxygenationchildrenhemolysisrenal replacement therapy

Identifiers

PMID30581228
PMCPMC6296454

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.