ArticleCell chemical biology2019
14-Helical β-Peptides Elicit Toxicity against C. albicans by Forming Pores in the Cell Membrane and Subsequently Disrupting Intracellular Organelles.
Article in Cell chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Repositioning Antimicrobial Peptides Against WHO-Priority Fungi.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Isolation of Antagonistic Bacterial Strains and Their Antimicrobial Volatile Organic Compounds AgainstEcology and evolution · 2025Article
- Exploring the frontiers of therapeutic breadth of antifungal peptides: A new avenue in antifungal drugs.Journal of industrial microbiology & biotechnology · 2024Review
- Establishing Quantifiable Guidelines for Antimicrobial α/β-Peptide Design: A Partial Least-Squares Approach to Improve Antimicrobial Activity and Reduce Mammalian Cell Toxicity.ACS infectious diseases · 2023Article
- Shifting archetype to nature's hidden gems: from sources, purification to uncover the nutritional potential of bioactive peptides.3 Biotech · 2023Review
- Specific Focus on Antifungal Peptides against Azole ResistantJournal of fungi (Basel, Switzerland) · 2022Review
- Antimicrobial Proteins: Structure, Molecular Action, and Therapeutic Potential.Pharmaceutics · 2022Review
- The Role ofPathogens (Basel, Switzerland) · 2022Article
- Mechanisms of Action of the Antimicrobial Peptide Cecropin in the Killing ofLife (Basel, Switzerland) · 2022Article
- Candidacidal and Antibiofilm Activity of PS1-3 Peptide against Drug-ResistantPharmaceutics · 2022Article
- Interactions of Bacterial Quorum Sensing Signals with Model Lipid Membranes: Influence of Acyl Tail Structure on Multiscale Response.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Bacterial Quorum Sensing Signals Promote Large-Scale Remodeling of Lipid Membranes.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions.Chemical Society reviews · 2021Review
- Activity and Mechanism of Action of Antifungal Peptides from Microorganisms: A Review.Molecules (Basel, Switzerland) · 2021Review
- Novel 2,4-Disubstituted-1,3-Thiazole Derivatives: Synthesis, Anti-Molecules (Basel, Switzerland) · 2020Article
- Characterization of the transcriptional response of Candida parapsilosis to the antifungal peptide MAF-1A.PeerJ · 2020Article
- β-Aminopeptidases: Insight into Enzymes without a Known Natural Substrate.Applied and environmental microbiology · 2019Article
- Bioactive Peptides Against Fungal Biofilms.Frontiers in microbiology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Synthetic peptidomimetics of antimicrobial peptides (AMPs) are promising antimicrobial drug candidates because they promote membrane disruption and exhibit greater structural and proteolytic stability than natural AMPs. We previously reported selective antifungal 14-helical β-peptides, but the mechanism of antifungal toxicity of β-peptides remains unknown. To provide insight into the mechanism, we studied antifungal β-peptide binding to artificial membranes and living Candida albicans cells. We investigated the ability of β-peptides to interact with and permeate small unilamellar vesicle models of fungal membranes. The partition coefficient supported a pore-mediated mechanism characterized by the existence of a critical β-peptide concentration separating low- and high-partition coefficient regimes. Live cell intracellular tracking of β-peptides showed that β-peptides translocated into the cytoplasm, and then disrupted the nucleus and vacuole sequentially, leading to cell death. This understanding of the mechanisms of antifungal activity will facilitate design and development of peptidomimetic AMPs, including 14-helical β-peptides, for antifungal applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.