Trial reportJournal of cardiothoracic and vascular anesthesia2019
A Comparison of Global Longitudinal, Circumferential, and Radial Strain to Predict Outcomes After Cardiac Surgery.
Trial report in Journal of cardiothoracic and vascular anesthesia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01187329 (The Effect of the Hyperinsulinemic Normoglycemic Clamp on Myocardial Function and Utilization of Glucose), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of the Hyperinsulinemic Normoglycemic Clamp on Myocardial Function and Utilization of Glucose
Who cites it
17 citing papers in PubMed.
- Exercise-induced changes in left ventricular strain are affected by interleukin-6 activity: An exploratory analysis of a randomised-controlled trial in humans with abdominal obesity.Experimental physiology · 2024Trial
- Automated cardiac strain estimation from short-axis DENSE and Cine MR images.Biomechanics and modeling in mechanobiology · 2026Article
- Effect of Immune Checkpoint Inhibitor Therapy on Biventricular and Biatrial Mechanics in Patients with Advanced Cancer: A Short-Term Follow-Up Study.Journal of clinical medicine · 2026Article
- Concomitant changes in regional myocardial deformation and intraventricular pressure gradients in normal and sedated goats: advanced multimodal echocardiographic study.BMC veterinary research · 2025Article
- Cardiac magnetic resonance parameters for prognostic stratification in pulmonary hypertension: A longitudinal study.Journal of the Chinese Medical Association : JCMA · 2025Article
- Post-cardiac arrest temporal evolution of left ventricular function in a rat model: speckle-tracking echocardiography and cardiac circulating biomarkers.European heart journal. Imaging methods and practice · 2024Article
- Multimodal ultrasound imaging of a rat model with ischemic heart failure and its relationship to histopathology.American journal of translational research · 2024Article
- Segmental and global longitudinal strain measurement by 2-dimensional speckle tracking echocardiography in severe rheumatic mitral stenosis.BMC cardiovascular disorders · 2023Article
- Left Ventricular "Longitudinal Rotation" and Conduction Abnormalities-A New Outlook on Dyssynchrony.Journal of clinical medicine · 2023Article
- Sequence and directivity in cardiac muscle injury of COVID-19 patients: an observational study.Frontiers in cardiovascular medicine · 2023Article
- The clinical application of longitudinal layer specific strain as a diagnostic and prognostic instrument in ischemic heart diseases: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- Dyspnea in pregnancy might be related to the incomplete physiological adaptation of the heart.Journal of cardiovascular and thoracic research · 2022Article
- Does types of atrial fibrillation matter in the impairment of global and regional left ventricular mechanics and intra-ventricular dyssynchrony?Frontiers in cardiovascular medicine · 2022Article
- Evaluation of Changes in the Cardiac Function before and after Transcatheter Edge-to-Edge Mitral Valve Repair in Healthy Dogs: Conventional and Novel Echocardiography.Animals : an open access journal from MDPI · 2021Article
- Effect of pericardial incision on left ventricular morphology and systolic function in patients during coronary artery bypass grafting.Cardiovascular ultrasound · 2020Article
- Post-cardiopulmonary bypass longitudinal strain provides higher prognostic ability than baseline strain or change in strain.Annals of cardiac anaesthesiaArticle
- Trend and Linearity Determination of Left Ventricular Mechanics in Cardiovascular Risk Factor Population with Preserved Ejection Fraction.Journal of cardiovascular echographyArticle
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Authors and funding
7 authors.
Funding
Abstract
objectiveMyocardial strain measured by speckle-tracking echocardiography detects subtle regional and global left ventricular dysfunction. Myocardial strain is measured in the longitudinal, circumferential, and radial dimensions; however, it is unclear which dimension of strain is the best predictor of postoperative outcomes.
designA secondary analysis of prospectively collected data from a clinical trial (NCT01187329).
settingThe cardiothoracic surgical operating rooms of an academic tertiary-care center.
participantsCardiothoracic surgery patients with aortic stenosis having aortic valve replacement (AVR) with or without coronary artery bypass grafting enrolled in a clinical trial.
interventionsMyocardial deformation analysis from standardized investigative transesophageal echocardiographic examinations performed after induction of anesthesia. MEASUREMENTS AND MAIN
resultsThe authors compared the ability of intraoperative global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) strain to predict adverse postoperative outcomes, including prolonged hospitalization and the need for pharmacologic hemodynamic support after cardiac surgery. The association of GLS, GCS, and GRS with prolonged hospitalization (>7 days) and the need for pharmacologic hemodynamic support, with epinephrine or norepinephrine after cardiopulmonary bypass, were assessed using separate multivariable logistic regression models with adjustment for multiple comparisons. Of 100 patients, 86 had acceptable measurements for GLS analysis, 73 for GCS, and 72 for GRS. Worse GLS was associated with prolonged hospitalization [odds ratio [OR] (98.3% confidence interval [CI]) of 1.21 (1.01-1.46) per-unit worsening in strain (p = 0.01, significance criterion <0.0167)] and the need for inotropic support with epinephrine [OR (99.2% CI) of 1.81 (1.10-2.97) per-unit worsening in strain (p = 0.002, significance criterion <0.0083)], but not norepinephrine. GCS and GRS were not associated with adverse outcomes.
conclusionGLS, but not GCS or GRS, predicts prolonged hospitalization and the requirement for inotropic support with epinephrine after AVR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.