ArticleJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2019
Differences in the lower airway microbiota of infants with and without cystic fibrosis.
Article in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Longitudinal development of the airway microbiota in infants with cystic fibrosis.Scientific reports · 2019Trial
- Longitudinal dynamics of respiratory microbiome composition in infants after new tracheostomy placement.BMJ open respiratory research · 2026Article
- Airway Microbiome in Children with Cystic Fibrosis: A Review of Microbial Shifts and Therapeutic Impacts.Medicina (Kaunas, Lithuania) · 2025Review
- Early nasal microbiota and subsequent respiratory tract infections in infants with cystic fibrosis.Communications medicine · 2024Article
- Microbiome-Mucosal Immunity Nexus: Driving Forces in Respiratory Disease Progression.Journal of microbiology (Seoul, Korea) · 2024Review
- The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease.Clinical reviews in allergy & immunology · 2023Review
- The human microbiome in disease and pathology.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2022Review
- The Impact of Highly Effective Modulator Therapy on Cystic Fibrosis Microbiology and Inflammation.Clinics in chest medicine · 2022Review
- Respiratory and Intestinal Microbiota in Pediatric Lung Diseases-Current Evidence of the Gut-Lung Axis.International journal of molecular sciences · 2022Review
- Early Lung Disease Exhibits Bacteria-Dependent and -Independent Abnormalities in Cystic Fibrosis Pigs.American journal of respiratory and critical care medicine · 2021Article
- Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease.Respiratory research · 2021Review
- Divergence of bacterial communities in the lower airways of CF patients in early childhood.PloS one · 2021Article
- The human respiratory tract microbial community structures in healthy and cystic fibrosis infants.NPJ biofilms and microbiomes · 2020Article
- Article
- Review
- Past, Present, and Future Research on the Lung Microbiome in Inflammatory Airway Disease.Chest · 2019Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundCystic fibrosis (CF) lung disease commences in infancy, and understanding the role of the microbiota in disease pathogenesis is critical. This study examined and compared the lower airway microbiota of infants with and without CF and its relationship to airway inflammation in the first months of life.
methodsInfants newly-diagnosed with CF were recruited into a single-centre study in Melbourne, Australia from 1992 to 2001. Bronchoalveolar lavage was performed at study entry. Healthy infants undergoing bronchoscopy to investigate chronic stridor acted as controls. Quantitative microbiological culture was performed and inflammatory markers were measured contemporaneously. 16S ribosomal RNA gene analysis was performed on stored samples.
resultsThirteen bronchoalveolar samples from infants with CF and nine from control infants, collected at median ages of 1.8-months (25th-75th percentile 1.5 to 3.1-months) and 5-months (25th-75th percentile 2.9 to 8.2-months) respectively, provided 16S rRNA gene data. Bacterial biomass was positively associated with inflammation. Alpha diversity was reduced in infants with CF and between-group compositional differences were apparent. These differences were driven by increased Staphylococcus and decreased Fusobacterium and were most apparent in symptomatic infants with CF.
conclusionIn CF lung disease, differences in lower airway microbial community composition and structure are established by age 6-months.
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