ArticleDental materials : official publication of the Academy of Dental Materials2019
Evidence to the role of interflavan linkages and galloylation of proanthocyanidins at sustaining long-term dentin biomodification.
Article in Dental materials : official publication of the Academy of Dental Materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Accessing Polyphenols Effect on Bond Strength and Dentin Enzymatic Degradation.Clinical and experimental dental research · 2026Article
- Long-term nano-dynamic mechanical analysis and micro-permeability of adhesive interface components using four AB-type proanthocyanidin neutral primers.Journal of dentistry · 2026Article
- The contribution of different types of polyphenols to bonding performance by enhancing the stabilization of the hybrid layer.Clinical oral investigations · 2026Article
- A Bioinspired Approach to Mechanically Reinforce Collagen-Rich Tissues Using Modularly Defined Stilbenoids.Biopolymers · 2026Article
- Biomineralization of dental tissues with natural drugs: a comprehensive review.The Saudi dental journal · 2025Review
- Optimization of dental adhesive interfaces using tissue biomodulation with DESIGNER biopolymers.Dental materials : official publication of the Academy of Dental Materials · 2025Article
- Regulatory potency of oligomeric proanthocyanidins (PACs) on extrafibrillar and intrafibrillar collagen mineralization.Journal of applied polymer science · 2025Article
- Prodelphinidins enhance dentin matrix properties and promote adhesion to methacrylate resin.Dental materials : official publication of the Academy of Dental Materials · 2024Article
- Does the pH of the grape seed extract interfere in the biomodification capacity of dentin collagen?Brazilian dental journal · 2024Article
- Fucosterol and Fucoxanthin Enhance Dentin Collagen Stability and Erosion Resistance Through Crosslinking and MMP Inhibition.International journal of nanomedicine · 2024Article
- Modulatory role of terminal monomeric flavan-3-ol units in the viscoelasticity of dentin.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- Unprecedented Benzoquinone Motifs Reveal Post-Oligomerizational Modification of Proanthocyanidins.The Journal of organic chemistry · 2023Article
- Development of Proanthocyanidin-Loaded Mesoporous Silica Nanoparticles for Improving Dental Adhesion.Molecular pharmaceutics · 2022Article
- A Food-Grade Method for Enhancing the Levels of Low Molecular Weight Proanthocyanidins with Potentially High Intestinal Bioavailability.International journal of molecular sciences · 2022Article
- B-type Proanthocyanidins with Dentin Biomodification Activity from Cocoa (Journal of agricultural and food chemistry · 2022Article
- Galloylated proanthocyanidins in dentin matrix exhibit biocompatibility and induce differentiation in dental stem cells.Journal of bioactive and compatible polymers · 2022Article
- Collagen Cross-Linking Lignin Improves the Bonding Performance of Etch-and-Rinse Adhesives to Dentin.Materials (Basel, Switzerland) · 2022Article
- Proanthocyanidin Tetramers and Pentamers fromJournal of natural products · 2022Article
- Paradoxical effects of galloyl motifs in the interactions of proanthocyanidins with collagen-rich dentin.Journal of biomedical materials research. Part A · 2022Article
- Unveiling structure-activity relationships of proanthocyanidins with dentin collagen.Dental materials : official publication of the Academy of Dental Materials · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThe interactivity of proanthocyanidins (PACs) with collagen modulates dentin matrix biomechanics and biostability. Herein, PAC extracts selected based on structural diversity were investigated to determine key PAC features driving sustained effects on dentin matrices over a period of 18months.
methodsThe chemical profiles of PAC-rich plant sources, Pinus massoniana (PM), Cinnamomum verum (CV) and Hamamelis virginiana (HV) barks, as well as Vitis vinifera (VV) seeds, were obtained by diol HPLC analysis after partitioning of the extracts between methyl acetate and water. Dentin matrices (n=15) were prepared from human molars to determine the apparent modulus of elasticity over 18months of aging. Susceptibility of the dentin matrix to degradation by endogenous and exogenous proteases was determined by presence of solubilized collagen in supernatant, and resistance to degradation by bacterial collagenase, respectively. Data were analyzed using ANOVA and Games-Howell post hoc tests (α=0.05).
resultsAfter 18months, dentin matrices modified by PM and CV extracts, containing only non-galloylated PACs, were highly stable mechanically (p<0.05). Dentin matrices treated with CV exhibited the lowest degradation by bacterial collagenase after 1h and 18months of aging (p<0.05), while dentin matrices treated with PM showed the least mass loss and collagen solubilization by endogenous enzymes over time (p<0.05). SIGNIFICANCE: Resistance against long-term degradation was observed for all experimental groups; however, the most potent and long-lasting dentin biomodification resulted from non-galloylated PACs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.