Evidence map›Paper›PMID 30580861›Full record

ArticleIndian heart journal

Biochemical and histological changes in the heart of post-partum rats exposed to Natron.

Yusuf Saidu, Maimuna Jumai Usman, Suleiman Ahmed Isa, Simeon Alabi Isezuo, Lawal Suleiman Bilbis, Saddiku Malam Sahabi, Ahmad Bello, Suleiman Alhaji Muhammad

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian heart journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yusuf SaiduDepartment of Biochemistry, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.
Maimuna Jumai UsmanDepartment of Biochemistry, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria. Electronic address: maimunatusman89@gmail.com.
Suleiman Ahmed IsaDepartment of Biochemistry, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.
Simeon Alabi IsezuoDepartment of Medicine, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.
Lawal Suleiman BilbisDepartment of Biochemistry, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.
Saddiku Malam SahabiDepartment of Histopathology, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.
Ahmad BelloDepartment of Biochemistry and Molecular Biology, Federal University, Birnin Kebbi, Nigeria.
Suleiman Alhaji MuhammadDepartment of Biochemistry, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.
Usmanu Danfodiyo University · NGFederal University Birnin Kebbi · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe customary puerperal practice of Natron consumption has been identified as one of the predisposing factors in the etiology of peripartum cardiomyopathy (PPCM). This study was designed to investigate the effect of Natron in postpartum Wistar albino rats.

methodsA total of 30 postpartum Wistar rats were exposed to different doses (50mg/kg, 100mg/kg, 200mg/kg and 300mg/kg) of Natron for 28days. After the treatment, we carried out biochemical analyses and histological evaluations of kidney, liver and heart.

resultsThe study revealed that the exposure of postpartum rats to 100mg/kg of Natron and above significantly (p<0.05) increase the cardiac markers; myoglobin, creatine kinase-MB, troponin I and T as compared with control. The result of liver function indicated no significant difference in alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, albumin and total protein of the Natron treated groups as compared with control. However, at higher doses, the levels of total protein, globulin and alkaline phosphatase activity were significantly increased in comparison to the control. There was no significant difference in the kidney function markers of the treatment groups as compared with control. Histological examinations revealed no changes in the kidney of the treated groups. Mild portal triaditis was observed in the liver of the treated rats. The heart of the rats administered ≥100mg/kg of Natron showed myocyte hypertrophy.

conclusionThe study demonstrated that the administration of Natron for 28days caused changes in the heart of postpartum rats and thus may contribute to the pathogenesis of PPCM.

Indexed as

Postpartum PeriodAnimalsBiomarkersCardiomyopathiesCreatine Kinase, MB FormDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleMyocardiumMyoglobinRatsRats, WistarSilicon DioxideSodium CholateTroponinBiomarkersCreatine Kinase, MB FormMyoglobinSilicon DioxideSodium CholateTroponinMyocyte hypertrophyNatronPeripartum cardiomyopathyPostpartumWistar rat

Identifiers

PMID30580861
PMCPMC6306309
OpenAlexW2775074673

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.