ArticleBiomedical journal2018
Depressant effect of geraniol on the central nervous system of rats: Behavior and ECoG power spectra.
Article in Biomedical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Subjective Effects of Inhaling Kuromoji Tea Aroma.Molecules (Basel, Switzerland) · 2021Trial
- Binary Mixtures of Essential Oils: Potent Housefly Adulticides That Are Safe Against Non-Target Species.Insects · 2025Article
- Article
- A comparative UPLC-orbitrap-MS-based metabolite profiling of three Pelargonium species cultivated in Egypt.Scientific reports · 2024Article
- Eucalyptus essential oil exerted a sedative-hypnotic effect by influencing brain neurotransmitters and gut microbes via the gut microbiota-brain axis.Frontiers in pharmacology · 2024Article
- Geraniol reverses obesity by improving conversion of WAT to BAT in high fat diet induced obese rats by inhibiting HMGCoA reductase.Nutrition & diabetes · 2023Article
- Review
- Predictions of the Biological Effects of Several Acyclic Monoterpenes as Chemical Constituents of Essential Oils Extracted from Plants.Molecules (Basel, Switzerland) · 2023Article
- Anxiolytic-like Effects and Quantitative EEG Profile of Palmitone Induces Responses Like Buspirone Rather Than Diazepam as Clinical Drugs.Molecules (Basel, Switzerland) · 2023Article
- Electroencephalographic Response in Juvenile Tambaqui,Biology · 2023Article
- Neuroprotective effect of geraniol on neurological disorders: a review article.Molecular biology reports · 2022Review
- Deeper Insight into the Volatile Profile ofMolecules (Basel, Switzerland) · 2022Article
- Sedative effects of l-menthol, d-camphor, phenylethyl alcohol, and geraniol.Journal of natural medicines · 2021Article
- Novel Intranasal Drug Delivery: Geraniol Charged Polymeric Mixed Micelles for Targeting Cerebral Insult as a Result of Ischaemia/Reperfusion.Pharmaceutics · 2020Article
- Dengue in Taiwan: Pointing the finger at Aedes aegypti.Biomedical journal · 2018Article
- Phytochemical and Therapeutic Potential ofJournal of evidence-based integrative medicineReview
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Geraniol is a monoterpene alcohol that is derived from the essential oils of aromatic plants, with anti-inflammatory, antimicrobial, antioxidant and neuroprotective properties. This study characterized the effect of geraniol on behavior and brainwave patterns in rats. Male rats were submitted to administration of geraniol (25, 50 and 100 mg/kg). The hole board (HB) and open field (OF) tests were performed to evaluate anxiety and motor behavior, respectively. In addition, barbiturate-induced sleeping time (BIST) was used to analyze sedative effect. Finally, electrocorticogram (ECoG) recordings were used to characterize brain-wave patterns. The results showed that geraniol treatment in rats decreased the distance traveled, rearing numbers and lead to increase in immobility time in HB and OF tests. In BIST test, geraniol treatment increased sleep duration but not sleep latency in the animals. Furthermore, geraniol-treated animals demonstrated an increase in the percentage of delta waves in the total spectrum power. Taken together, our results suggested that geraniol exerted a depressant effect on the central nervous system of rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.