ArticleHypertension (Dallas, Tex. : 1979)2019
Role of Corin in Blood Pressure Regulation in Normotensive and Hypertensive Pregnancy.
Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024Guideline
- Muscle sympathetic nerve activity during pregnancy: A systematic review and meta-analysis.Physiological reports · 2023Pooled it
- Impact of Gestational Weight Gain and Maternal Weight on Sympathetic Adaptations.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Nonlinear association between first-trimester plasma aldosterone concentration and risk of hypertensive disorders of pregnancy: a multicenter prospective cohort study.Frontiers in endocrinology · 2026Article
- Longitudinal changes in cardiovascular and sympathetic neural responses to static handgrip exercise throughout pregnancy.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Analysis of Circulating Catestatin in Early Pregnancy: A Preliminary Investigation.Biomedicines · 2024Article
- Impact of maternal obesity on resting muscle sympathetic nerve activity during uncomplicated pregnancy: a longitudinal assessment.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Causes and consequences of sympathoexcitation across the lifespan: Physiological or pathological?Experimental physiology · 2023Article
- The sympathetic nervous system in healthy and hypertensive pregnancies: physiology or pathology?Experimental physiology · 2023Review
- Muscle Sympathetic Action Potential Firing Patterns During Normotensive and Hypertensive Pregnancy: A Longitudinal Assessment.Circulation · 2023Article
- Differential regulation of sympathetic neural burst frequency and amplitude throughout normal pregnancy: a longitudinal study.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Sympathetic Action Potential Firing and Recruitment Patterns Are Abnormal in Gestational Hypertension.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Corin-The Early Marker of Preeclampsia in Pregestational Diabetes Mellitus.Journal of clinical medicine · 2022Article
- Posture-related changes in sympathetic baroreflex sensitivity during normal pregnancy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Soluble Corin Predicts the Risk of Cardiovascular Disease: A 10-Year Follow-Up Study.JACC. Asia · 2022Article
- Review
- Correlation between N-terminal pro-atrial natriuretic peptide, corin, and target organ damage in hypertensive disorders of pregnancy.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Atrial natriuretic peptide promotes uterine decidualization and a TRAIL-dependent mechanism in spiral artery remodeling.The Journal of clinical investigation · 2021Article
- Neural control of blood pressure during pregnancy in humans.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Review
- Influence of multiparity on sympathetic nerve activity during normal pregnancy.American journal of physiology. Heart and circulatory physiology · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Corin (an atrial natriuretic peptide-converting enzyme) represents a potential biomarker for gestational hypertensive disorders; yet, its role in blood pressure (BP) regulation throughout pregnancy remains unclear. We investigated the time course of change in blood corin content in relation to BP and sympathetic nerve activity throughout pregnancy. Forty-four women (29±0.9 years) participated. Following-term, 23 had low-risk (no personal history of gestational hypertensive disorders) normal pregnancies, 13 had high-risk (personal history of gestational hypertensive disorders) normal pregnancies, and 8 developed gestational hypertension. BP, heart rate, muscle sympathetic nerve activity, and serum corin were measured before pregnancy, during early (4-8 weeks) and late pregnancy (32-36 weeks), and postpartum (6-10 weeks). Overall, compared with prepregnancy, corin remained unchanged during early pregnancy, increased markedly during late pregnancy ( P<0.001), and returned to prepregnancy levels postpartum. In women who developed gestational hypertension, the change in corin from early to late pregnancy was greater than those with low-risk normal pregnancies (Δ971±134 versus Δ486±79 pg/mL; P<0.05). Throughout pregnancy, BP and muscle sympathetic nerve activity were augmented in women with gestational hypertension (all P<0.05). Finally, changes in corin from early to late pregnancy were related to all indices of BP ( R=0.454-0.551; all P<0.01) in late pregnancy, whereas burst frequency, burst incidence, and total muscle sympathetic nerve activity ( R=0.576-0.614; all P<0.001) in early pregnancy were related to changes in corin from early to late pregnancy. Corin plays a unique role in BP regulation throughout normotensive and, especially, hypertensive pregnancy and may represent a promising biomarker for determining women at high risk of adverse pregnancy outcome.
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Registered trials
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