ArticleArteriosclerosis, thrombosis, and vascular biology2019
Proteins Altered by Surgical Weight Loss Highlight Biomarkers of Insulin Resistance in the Community.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Pooled it
- High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control.Nature communications · 2021Trial
- Proteomic profiles before and during weight loss: Results from randomized trial of dietary intervention.Scientific reports · 2020Trial
- Adiposity and cancer: epidemiology, mechanisms and future perspectives.Nature metabolism · 2026Review
- Tissue-specific roles of IGFBP2 in glucose and lipid metabolism in obesity-related metabolic diseases.Frontiers in nutrition · 2026Review
- Post-transcriptional modifications on tRNA fragments confer functional changes to high-density lipoproteins in atherosclerosis.Atherosclerosis · 2026Article
- Assessing the impact of bariatric surgery on cardiovascular risk in type 2 diabetes: a systematic review and meta-analysis using OMICs data.Diabetology & metabolic syndrome · 2025Review
- Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities.Nature medicine · 2025Article
- The BAMBOO method for correcting batch effects in high throughput proximity extension assays for proteomic studies.Scientific reports · 2025Article
- Characterization of the plasma metabolome and lipidome in response to sleeve gastrectomy and gastric bypass surgeries reveals molecular patterns of surgical weight loss.Metabolism: clinical and experimental · 2024Article
- Using trials of caloric restriction and bariatric surgery to explore the effects of body mass index on the circulating proteome.Scientific reports · 2023Article
- Proteomics, dietary intake, and changes in cardiometabolic health within a behavioral weight-loss intervention: A pilot study.Obesity (Silver Spring, Md.) · 2022Article
- Proteome-wide associations with short- and long-term weight loss and regain after Roux-en-Y gastric bypass surgery.Obesity (Silver Spring, Md.) · 2022Article
- More frequent olive oil intake is associated with reduced platelet activation in obesity.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2021Article
- Cardiovascular Biomarkers of Obesity and Overlap With Cardiometabolic Dysfunction.Journal of the American Heart Association · 2021Article
- IGFBP-2 partly mediates the early metabolic improvements caused by bariatric surgery.Cell reports. Medicine · 2021Article
- The Dynamic Platelet Transcriptome in Obesity and Weight Loss.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance.International journal of molecular sciences · 2021Review
- Effects of gastric sleeve surgery on the serum levels of GH, IGF-1 and IGF-binding protein 2 in healthy obese patients.BMC gastroenterology · 2020Article
- Biomarker-defined pathways for incident type 2 diabetes and coronary heart disease-a comparison in the MONICA/KORA study.Cardiovascular diabetology · 2020Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
Abstract
Objective- Mechanisms of early and late improvements in cardiovascular risk after bariatric surgery and applicability to larger, at-risk populations remain unclear. We aimed to identify proteins altered after bariatric surgery and their relations to metabolic syndrome and diabetes mellitus. Approach and Results- We identified 19 proteins altered in 32 nonfasting plasma samples from a study of patients undergoing bariatric surgery who were evaluated preoperatively (visit 1) versus both early (visit 2; ≈3 months) and late (visit 3; ≈12 months) postoperative follow-up using predefined protein panels (Olink). Using in silico methods and publicly available gene expression repositories, we found that genes encoding 8 out of 19 proteins had highest expression in liver relative to other assayed tissues, with the top biological and disease processes, including major obesity-related vascular diseases. Of 19 candidate proteins in the surgical cohort, 6 were previously measured in >3000 FHS (Framingham Heart Study) participants (IGFBP [insulin-like growth factor binding protein]-1, IGFBP-2, P-selectin, CD163, LDL (low-density lipoprotein)-receptor, and PAI [plasminogen activator inhibitor]-1). A higher concentration of IGFBP-2 at baseline was associated with a lower risk of incident metabolic syndrome (odds ratio per log-normal unit, 0.45; 95% CI, 0.32-0.64; P=7.7×10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.