ArticleSleep & breathing = Schlaf & Atmung2019
Sex differences in mandibular repositioning device therapy effectiveness in patients with obstructive sleep apnea syndrome.
Article in Sleep & breathing = Schlaf & Atmung, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01326143 (ORM Narval Mandibular Repositioning Device in the Second-line Treatment of Severe OSAH), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ORM Narval Mandibular Repositioning Device in the Second-line Treatment of Severe OSAH
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Gender Differences in the Context of Obstructive Sleep Apnea and Metabolic Diseases.Frontiers in physiology · 2021Pooled it
- The comparison of two different mandibular positions for oral appliance therapy in patients with obstructive sleep apnea.Clinical and experimental dental research · 2022Trial
- Mandibular Advancement Device Therapy in 182 DISE-Selected Adults with Moderate-to-Severe Obstructive Sleep Apnea: A Multicenter Real-World Study.Biomedicines · 2026Article
- Advances in the Diagnosis and Treatment of Obstructive Sleep Apnea in Women.Pulmonary therapy · 2026Review
- Sex- and age-differences in supine positional obstructive sleep apnea in children and adults.Sleep & breathing = Schlaf & Atmung · 2025Article
- Gender differences in oral appliance treatment of obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Objectively measured adherence may affect side effects of mandibular advancement therapy in subjects with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Gender medicine and sleep disorders: from basic science to clinical research.Frontiers in neurology · 2024Review
- A Narrative Review of Sex and Gender Differences in Sleep Disordered Breathing: Gaps and Opportunities.Life (Basel, Switzerland) · 2022Review
- Mandibular advancement device use in obstructive sleep apnea: ORCADES study 5-year follow-up data.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Mandibular Advancement Devices for OSA: An Alternative to CPAP?Pulmonary therapy · 2021Review
- Sex differences in obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2019Review
- Oral Appliance Therapy for Obstructive Sleep Apnoea: State of the Art.Journal of clinical medicine · 2019Review
- Update on oral appliance therapy.European respiratory review : an official journal of the European Respiratory Society · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
80 authors at 14 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMandibular repositioning devices (MRDs) are an effective treatment option for obstructive sleep apnea syndrome (OSAS), particularly in patients who refuse or cannot tolerate continuous positive airway pressure (CPAP). However, sex differences in the response to therapy and predictors of response are not clearly defined. This analysis of data from the long-term prospective ORCADES trial compared MRD efficacy in men and women with OSAS.
methodsThe ORCADES study included patients with newly diagnosed mild-to-moderate or severe OSAS who refused or were non-compliant with CPAP. MRD therapy was titrated over 3-6 months. The primary endpoint was treatment success (≥ 50% decrease in apnea-hypopnea index (AHI)). Complete response was defined using a range of AHI cut-off values (< 5/h, < 10/h, < 15/h).
resultsOverall treatment success rates were 89% in women and 76% in men (p = 0.019); corresponding rates in those with severe OSAS (AHI > 30/h) were 100% and 68% (p = 0.0015). In women vs. men, overall complete response rates at AHI cut-off values of < 5/h, <10/h, and < 15/h were 49 vs. 34% (p = 0.0052), 78 vs. 62% (p = 0.016), and 92 vs. 76% (p = 0.0032). On multivariate analysis, significant predictors of MRD treatment success were overbite and baseline apnea index in men, and neck circumference and no previous CPAP therapy in women. There were sex differences in the occurrence of side effects. Temporomandibular joint pain was the most common reason for stopping MRD therapy.
conclusionsMRD therapy was effective in women with OSA of any severity, with significantly higher response rates compared with men especially in severe OSAS.
trial registrationwww.clinicaltrials.gov (NCT01326143).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.