ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019
Imaging features (CT, MRI, MRS, and PET/CT) of primary central nervous system lymphoma in immunocompetent patients.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 56 citations in OpenAlex.
- Radiological and FDG-PET imaging features of Epstein-Barr virus-positive primary central nervous system lymphomas.Journal of neurology · 2026Article
- A case report: primary central nervous system lymphoma misdiagnosed as neuromyelitis optica.BMC neurology · 2026Article
- Diagnostic imaging and emerging image-guided neurointervention in brain tumors: a narrative review.Frontiers in radiology · 2026Review
- Lymphedema is a rare manifestation of lymphoma: A case series and literature review.Oncology letters · 2025Article
- Clinical characteristics and prognosis of ventricular primary central nervous system lymphoma: a case series and literature review.Chinese neurosurgical journal · 2025Article
- Investigation of MRI features in subtypes of primary central nervous system diffuse large B-cell lymphoma.BMC medical imaging · 2025Article
- The "purfling sign": a new imaging marker for the diagnosis of primary CNS lymphoma.La Radiologia medica · 2025Article
- Primary Intraocular Lymphoma: Rad-Path and Ophthalmologic Correlation.AJNR. American journal of neuroradiology · 2025Article
- Radiomics model building from multiparametric MRI to predict Ki-67 expression in patients with primary central nervous system lymphomas: a multicenter study.BMC medical imaging · 2025Article
- Differentiating between Lymphoma and Metastasis Presenting as Solid Cerebellar Mass Lacking Necrosis.Diagnostics (Basel, Switzerland) · 2024Article
- Primary central nervous system lymphomas in immunocompromised patients require specific response criteria.Journal of neuro-oncology · 2024Article
- Magnetic resonance imaging findings in central nervous system tuberculosis: A pictorial review.Heliyon · 2024Review
- Article
- MRI radiomics-based interpretable model and nomogram for preoperative prediction of Ki-67 expression status in primary central nervous system lymphoma.Frontiers in medicine · 2024Article
- Primary large B-cell lymphoma of the central nervous system misdiagnosed as autoimmune encephalitis: a case report.Frontiers in oncology · 2024Article
- Neurosurgical Management of Central Nervous System Lymphoma: Lessons Learnt from a Neuro-Oncology Multidisciplinary Team Approach.Journal of personalized medicine · 2023Article
- Article
- Review
- Evidence-based expert consensus on the management of primary central nervous system lymphoma in China.Journal of hematology & oncology · 2022Review
- Analysis of Key Factors Associated with Response to Salvage High-Dose Methotrexate Rechallenge in Primary Central Nervous System Lymphoma with First Relapse.Current oncology (Toronto, Ont.) · 2022Article
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2 authors at 1 institution in 1 country.
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Abstract
backgroundBecause of the low incidence of primary central nervous system lymphoma (PCNSL) in non-HIV individuals and because of the lack of specific clinical manifestations and auxiliary examinations, the disease is easily missed or misdiagnosed.
objectiveTo analyze the imaging features of PCNSL in non-HIV patients.
methodsThis was a retrospective study of patients with PCNSL treated between January 2001 and December 2011 at the Naval General Hospital (Beijing, China). All included patients were pathologically diagnosed with PCNSL. Specimens were obtained by stereotactic biopsy and diagnosed by pathological examination. Serological panel had to be negative for HIV.
resultsOut of the 118 patients, 73 (61.9%) were male and 45 (38.1%) were female. Median age was 54 (range 11-83) years. All patients had B cell lymphoma. The lesions showed slightly hyperintense shadows on computed tomography (CT) images, and mostly hyperintense T1 and iso- or hyperintense T2 signals on magnetic resonance imaging (MRI). Most lesions showed patchy enhancement after enhanced scanning, and some had the characteristic "butterfly sign" on enhanced MRI. The magnetic resonance spectroscopy of PCNSL manifested as increased Cho peak, moderately decreased NAA peak, and slightly decreased Cr peak. Positron emission computed tomography indicated high metabolism of
conclusionMRI is important in the diagnosis of PCNSL. Understanding the imaging features of PCNSL will help improve its diagnosis in clinics.
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