Evidence map›Paper›PMID 30580379›Full record

Observational studyInternational journal of clinical oncology2019

A multi-institutional observational study on the effects of three-dimensional radiotherapy and weekly 40-mg/m

Fumiaki Isohashi, Tadao Takano, Mamiko Onuki, Takahide Arimoto, Naoki Kawamura, Ryusuke Hara, Yoshiaki Kawano, Yukinobu Ota, Haruo Inokuchi, Hidenori Shinjo and 10 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in International journal of clinical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Fumiaki IsohashiDepartment of Radiation Oncology, Osaka University Graduate School of Medicine, 2-2 (D10) Yamadaoka, Suita, Osaka, 565-0871, Japan. isohashi@radonc.med.osaka-u.ac.jp.ORCID http://orcid.org/0000-0001-6342-4693
Tadao TakanoDepartment of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan.
Mamiko OnukiDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Takahide ArimotoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Naoki KawamuraDepartment of Gynecology, Osaka City General Hospital, Osaka, Japan.
Ryusuke HaraDivision of Radiation Oncology, Chiba Cancer Center, Chiba, Japan.
Yoshiaki KawanoDepartment of Gynecology and Obstetrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yukinobu OtaDepartment of Gynecology, Osaka International Cancer Institute, Osaka, Japan.
Haruo InokuchiDepartment of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hidenori ShinjoDepartment of Radiation Oncology, Showa University Hospital, Tokyo, Japan.
Toshiaki SaitoGynecology Service, National Kyushu Cancer Center, Fukuoka, Japan.
Satoe FujiwaraDepartment of Obstetrics and Gynecology, Osaka Medical College, Osaka, Japan.
Takashi SawasakiDepartment of Gynecology, National Hospital Organization Kure Medical Center, Kure, Japan.
Ken AndoDepartment of Radiation Oncology, Gunma Prefectural Cancer Center, Gunma, Japan.
Koji HorieDepartment of Gynecology, Saitama Cancer Center, Saitama, Japan.
Hiroyuki OkamotoDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.
Naoya MurakamiDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.
Yoko HasumiDepartment of Obstetrics and Gynecology, Mitsui Memorial Hospital, Tokyo, Japan.
Takahiro KasamatsuDepartment of Obstetrics and Gynecology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan.
Takafumi ToitaDepartment of Radiology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to evaluate the effects of treatment with both three-dimensional radiotherapy (3DRT) and weekly 40-mg/m

methodsWe conducted a retrospective multi-institutional chart review of postoperative uterine cervical cancer patients with high-risk prognostic factors who had been treated with both 3DRT and weekly 40-mg/m

resultsThe eligible 96 patients were analyzed. The median follow-up period was 61 months. The 3-year relapse-free survival, overall survival (OS), and locoregional relapse-free survival (LRFS) rates were 76%, 90%, and 88%, respectively. In multivariate analysis, the histological finding of either adenocarcinoma or adenosquamous carcinoma was a significant risk factor for both OS and LRFS. The percentage of patients with grade ≥ 3 acute hematologic toxicity, acute lower gastrointestinal toxicity (GIT), and late lower GIT were 45%, 19%, and 17%, respectively.

conclusionsThe outcomes of concurrent chemoradiotherapy (CCRT) using weekly 40-mg/m

Indexed as

AdenocarcinomaAdultAntineoplastic AgentsCarcinoma, AdenosquamousChemoradiotherapyCisplatinDrug Administration ScheduleFemaleHumansMiddle AgedNeoplasm Recurrence, LocalPostoperative PeriodPrognosisRetrospective StudiesSurvival RateTreatment OutcomeAntineoplastic AgentsCisplatinCervical cancerCisplatinConcurrent chemoradiotherapyPostoperativeThree-dimensional radiotherapy

Identifiers

PMID30580379
PMCPMC6469659

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.