Evidence map›Paper›PMID 30580277›Full record

ArticleBMJ open2018

Randomised controlled study comparing general and spinal anaesthesia with and without a tourniquet on the outcomes of total knee arthroplasty: study protocol.

Mikko Tuomas Rantasalo, Riku Palanne, Katarina Juutilainen, Pekka Kairaluoma, Rita Linko, Elina Reponen, Teemu Helkamaa, Anne Vakkuri, Klaus T Olkkola, Rami Madanat and 1 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03364088 (Outcome After Total Knee Arthroplasty Under General or Spinal Anesthesia, a Randomized Controlled Trial), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03364088 nacompletednot on this map

Outcome After Total Knee Arthroplasty Under General or Spinal Anesthesia, a Randomized Controlled Trial

TypeinterventionalSponsorRiku Antero PalanneRan2016 to 2019Enrolled402ConditionsKnee Osteoarthritis, Arthropathy of Knee Joint, Knee Pain Chronic, Rheumatoid ArthritisArmsSpinal anesthesia with tourniquet, Spinal anesthesia without tourniquet, General anesthesia with tourniquet, General anesthesia without tourniquet, Oxycodone by patient-controlled analgesia (PCA)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Mikko Tuomas RantasaloPeijas Hospital, Department of Orthopaedics and Traumatology, Arthroplasty Centre, University of Helsinki and Helsinki University Hospital, Vantaa, Finland.ORCID 0000-0002-9688-209X
Riku PalannePeijas Hospital, Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Vantaa, Finland.
Katarina JuutilainenPeijas Hospital, Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Vantaa, Finland.
Pekka KairaluomaPeijas Hospital, Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Vantaa, Finland.
Rita LinkoPeijas Hospital, Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Vantaa, Finland.
Elina ReponenPeijas Hospital, Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Vantaa, Finland.
Teemu HelkamaaPeijas Hospital, Department of Orthopaedics and Traumatology, Arthroplasty Centre, University of Helsinki and Helsinki University Hospital, Vantaa, Finland.
Anne VakkuriPeijas Hospital, Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Vantaa, Finland.
Klaus T OlkkolaDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Rami MadanatPeijas Hospital, Department of Orthopaedics and Traumatology, Arthroplasty Centre, University of Helsinki and Helsinki University Hospital, Vantaa, Finland.
Noora Kati Annukka SkantsPeijas Hospital, Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Vantaa, Finland.
University of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTotal knee arthroplasty is a highly effective treatment for end-stage knee osteoarthritis, and it is usually performed under spinal or general anaesthesia with or without a surgical tourniquet. Some debate about the preferred mode of anaesthesia regarding patient outcomes remains. The aim of this study, which compares general and spinal anaesthesia with and without a tourniquet on the outcomes of total knee arthroplasty, is to determine the optimal type of anaesthesia regimen and assess the effect of a tourniquet on the patient's recovery following total knee arthroplasty. METHODS AND ANALYSIS: This study is a randomised, controlled, parallel-group, four-arm study comparing spinal and general anaesthesia with and without a tourniquet in 400 patients undergoing fast-track total knee arthroplasty, with a 12-month follow-up. The primary outcome is cumulative intravenous oxycodone consumption by patient-controlled analgesia during the first 24 postoperative hours. Secondary outcomes include postoperative nausea and vomiting, the length of hospital stay, the duration of the surgery, blood loss, demand for surgical unit resources, complications, readmissions, postoperative knee function, range of motion, health-related quality of life, prolonged pain and mortality. ETHICS AND DISSEMINATION: This study's protocol is in accordance with the declaration of Helsinki. The results of this study will be disseminated in international peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT03364088; Pre-results.

Indexed as

Anesthesia, GeneralAnesthesia, SpinalTourniquetsAnalgesia, Patient-ControlledArthroplasty, Replacement, KneeComparative Effectiveness ResearchHumansLength of StayOsteoarthritis, KneePostoperative ComplicationsQuality of LifeRandomized Controlled Trials as TopicRange of Motion, ArticularTreatment Outcomeanaesthesia In orthopaedicsclinical trialskneepain management

Identifiers

PMID30580277
PMCPMC6307602
OpenAlexW2906392328

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.