ReviewEpilepsy & behavior : E&B2019
Driving status of patients with generalized spike-wave on EEG but no clinical seizures.
Review in Epilepsy & behavior : E&B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Naturalistic driving behavior among older adults with and without epilepsy: A pilot study.Epilepsy & behavior : E&B · 2025Article
- Clinical utility of an ambulatory absence seizure detection system.Epilepsia open · 2025Article
- Tailoring antiseizure treatment with a wearable device: A proof-of-concept study in absence epilepsy.Epilepsia · 2025Article
- The Diagnostic Value of EEG Wave Trains for Distinguishing Immature Absence Seizures and Sleep Spindles: Evidence from the WAG/Rij Rat Model.Diagnostics (Basel, Switzerland) · 2025Article
- Electroencephalographic compatibility with fitness to drive: A nationwide survey among Swiss neurologists.Epilepsia open · 2024Article
- From an idea to the marketplace: Identifying and addressing ethical and regulatory considerations across the digital health product-development lifecycle.BMC digital health · 2024Article
- Seizure reduction in TSC2-mutant mouse model by an mTOR catalytic inhibitor.Annals of clinical and translational neurology · 2023Article
- Predictive Power of Interictal Epileptiform Discharges in Fitness-to-Drive Evaluation.Neurology · 2023Article
- Ethical considerations for researchers developing and testing minimal-risk devices.Nature communications · 2023Article
- Dexmedetomidine, an alpha 2A receptor agonist, triggers seizures unilaterally in GAERS during the pre-epileptic phase: does the onset of spike-and-wave discharges occur in a focal manner?Frontiers in neurology · 2023Article
- Quantitative EEG analysis in typical absence seizures: unveiling spectral dynamics and entropy patterns.Frontiers in human neuroscience · 2023Article
- A machine-learning approach for predicting impaired consciousness in absence epilepsy.Annals of clinical and translational neurology · 2022Article
- Accurate detection of typical absence seizures in adults and children using a two-channel electroencephalographic wearable behind the ears.Epilepsia · 2021Article
- Abnormal Rat Cortical Development Induced by Ventricular Injection of rHMGB1 Mimics the Pathophysiology of Human Cortical Dysplasia.Frontiers in cell and developmental biology · 2021Article
- Article
- The Drives for Driving Simulation: A Scientometric Analysis and a Selective Review of Reviews on Simulated Driving Research.Frontiers in psychology · 2020Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Generalized spike-wave discharges (SWDs) are the hallmark of generalized epilepsy on the electroencephalogram (EEG). In clinically obvious cases, generalized SWDs produce myoclonic, atonic/tonic, or absence seizures with brief episodes of staring and behavioral unresponsiveness. However, some generalized SWDs have no obvious behavioral effects. A serious challenge arises when patients with no clinical seizures request driving privileges and licensure, yet their EEG shows generalized SWD. Specialized behavioral testing has demonstrated prolonged reaction times or missed responses during SWD, which may present a driving hazard even when patients or family members do not notice any deficits. On the other hand, some SWDs are truly asymptomatic in which case driving privileges should not be restricted. Clinicians often decide on driving privileges based on SWD duration or other EEG features. However, there are currently no empirically-validated guidelines for distinguishing generalized SWDs that are "safe" versus "unsafe" for driving. Here, we review the clinical presentation of generalized SWD and recent work investigating mechanisms of behavioral impairment during SWD with implications for driving safety. As a future approach, computational analysis of large sets of EEG data during simulated driving utilizing machine learning could lead to powerful methods to classify generalized SWD as safe vs. unsafe. This may ultimately provide more objective EEG criteria to guide decisions on driving safety in people with epilepsy.
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