Evidence map›Paper›PMID 30580036›Full record

ArticleJournal of molecular biology2019

Structural and Biochemical Characterization of Aldehyde Dehydrogenase 12, the Last Enzyme of Proline Catabolism in Plants.

David A Korasick, Radka Končitíková, Martina Kopečná, Eva Hájková, Armelle Vigouroux, Solange Moréra, Donald F Becker, Marek Šebela, John J Tanner, David Kopečný

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Measurement of δMetabolites · 2025
    Article
  2. The Aldehyde Dehydrogenase Superfamily inInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Differential Expression of Stress Adaptation Genes in a DiatomInternational journal of molecular sciences · 2024
    Article
  6. Structural Insight into the Catalytic Mechanisms of an L-Sorbosone Dehydrogenase.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

David A KorasickDepartment of Biochemistry, University of Missouri, Columbia, MO 65211, USA.
Radka KončitíkováDepartment of Protein Biochemistry and Proteomics, Centre of the Region Haná for Biotechnological and Agricultural Research, Palacký University, Olomouc, CZ 78371, Czech Republic.
Martina KopečnáDepartment of Protein Biochemistry and Proteomics, Centre of the Region Haná for Biotechnological and Agricultural Research, Palacký University, Olomouc, CZ 78371, Czech Republic.
Eva HájkováDepartment of Protein Biochemistry and Proteomics, Centre of the Region Haná for Biotechnological and Agricultural Research, Palacký University, Olomouc, CZ 78371, Czech Republic.
Armelle VigourouxInstitute for Integrative Biology of the Cell (I2BC), CNRS-CEA-Univ. Paris-Sud, Université Paris-Saclay, Avenue de la Terrasse, F-91198 Gif-sur-Yvette, France.
Solange MoréraInstitute for Integrative Biology of the Cell (I2BC), CNRS-CEA-Univ. Paris-Sud, Université Paris-Saclay, Avenue de la Terrasse, F-91198 Gif-sur-Yvette, France.
Donald F BeckerDepartment of Biochemistry, Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE, USA.
Marek ŠebelaDepartment of Protein Biochemistry and Proteomics, Centre of the Region Haná for Biotechnological and Agricultural Research, Palacký University, Olomouc, CZ 78371, Czech Republic.
John J TannerDepartment of Biochemistry, University of Missouri, Columbia, MO 65211, USA; Department of Chemistry, University of Missouri, Columbia, MO 65211, USA. Electronic address: tannerjj@missouri.edu.
David KopečnýDepartment of Protein Biochemistry and Proteomics, Centre of the Region Haná for Biotechnological and Agricultural Research, Palacký University, Olomouc, CZ 78371, Czech Republic. Electronic address: david.kopecny@upol.cz.
Palacký University Olomouc · CZUniversity of Missouri · US

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
Substrate Channeling and Communication in Proline Metabolic EnzymesR01GM065546 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI Donald F Becker, JOHN J TANNER · 2002 to 2026
$5.0M
Integrated Prediction of Protein Struture at 1D, 2D and 3D LevelsR01GM093123 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHENG, JIANLIN · 2010 to 2023
$3.8M
MINOS (Macromolecular Insights on Nucleic acids Optimized by Scattering)R01GM105404 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI TAINER, JOHN A. · 2012 to 2015
$2.1M
NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM065546NIGMS NIH HHS R01 GM093123NIGMS NIH HHS R01 GM105404
6 · The paper itself

Abstract

Heterokonts, Alveolata protists, green algae from Charophyta and Chlorophyta divisions, and all Embryophyta plants possess an aldehyde dehydrogenase (ALDH) gene named ALDH12. Here, we provide a biochemical characterization of two ALDH12 family members from the lower plant Physcomitrella patens and higher plant Zea mays. We show that ALDH12 encodes an NAD

Indexed as

Aldehyde DehydrogenaseCrystallography, X-RayPhylogenyPlantsProlineSubstrate SpecificityAldehyde DehydrogenaseProlineALDH12glutamate γ-semialdehydePhyscomitrella patensprolineZea mays

Identifiers

PMID30580036
PMCPMC6365017
OpenAlexW2906427719

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.