Evidence map›Paper›PMID 30579884›Full record

ArticleNeuropharmacology2019

Effects of chronic caffeine exposure during adolescence and subsequent acute caffeine challenge during adulthood on rat brain serotonergic systems.

M R Arnold, P H Williams, J A McArthur, A R Archuleta, C E O'Neill, J E Hassell, D G Smith, R K Bachtell, C A Lowry

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

M R ArnoldDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA; Center for Neuroscience, University of Colorado Boulder, Boulder, CO, 80309, USA. Electronic address: arnoldmr@colorado.edu.
P H WilliamsDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA. Electronic address: piper.williams@colorado.edu.
J A McArthurDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA. Electronic address: jessica.mcarthur@colorado.edu.
A R ArchuletaCenter for Neuroscience, University of Colorado Boulder, Boulder, CO, 80309, USA; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, 80309, USA. Electronic address: Solana.Archuleta@colorado.edu.
C E O'NeillCenter for Neuroscience, University of Colorado Boulder, Boulder, CO, 80309, USA; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, 80309, USA. Electronic address: casey.oneill@colorado.edu.
J E HassellDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA. Electronic address: james.hassell@colorado.edu.
D G SmithDepartment of Chemistry and Biochemistry, University of Colorado Boulder, Boulder, CO, 80309, USA. Electronic address: dasm3869@colorado.edu.
R K BachtellCenter for Neuroscience, University of Colorado Boulder, Boulder, CO, 80309, USA; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, 80309, USA. Electronic address: ryan.bachtell@colorado.edu.
C A LowryDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA; Center for Neuroscience, University of Colorado Boulder, Boulder, CO, 80309, USA; Department of Physical Medicine & Rehabilitation and Center for Neuroscience, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA; Veterans Health Administration, Rocky Mountain Mental Illness Research Education and Clinical Center, Denver Veterans Affairs Medical Center (VAMC), Denver, CO, 80220, USA; Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE), Denver, CO, 80220, USA. Electronic address: christopher.lowry@colorado.edu.
University of Colorado Boulder · US

Funding

Adenosine Receptor Involvement in Methamphetamine Reward and RelapseR01DA033358 · NIDA · UNIVERSITY OF COLORADO · PI BACHTELL, RYAN K · 2013 to 2017
$1.9M
Mycobacterium vaccae and stress resilience: Neural mechanismsR21MH116263 · NIMH · UNIVERSITY OF COLORADO · PI FRANK, MATTHEW G, LOWRY, CHRISTOPHER A · 2018 to 2019
$424k
Biological Signature and Safety of an Immunomodulatory Probiotic Intervention for Veterans with Co-Occuring Mild TBI and PTSDI21RX002232 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI BRENNER, LISA A · 2016 to 2018
–
NIDA NIH HHS R01 DA033358NIMH NIH HHS R21 MH116263RRD VA I21 RX002232
6 · The paper itself

Abstract

Caffeine is the most commonly used drug in the world. However, animal studies suggest that chronic consumption of caffeine during adolescence can result in enhanced anxiety-like behavioral responses during adulthood. One mechanism through which chronic caffeine administration may influence subsequent anxiety-like responses is through actions on brainstem serotonergic systems. In order to explore potential effects of chronic caffeine consumption on brainstem serotonergic systems, we evaluated the effects of a 28-day exposure to chronic caffeine (0.3 g/L; postnatal day 28-56) or vehicle administration in the drinking water, followed by 24 h caffeine withdrawal, and subsequent challenge with caffeine (30 mg/kg; s.c.) or vehicle in adolescent male rats. In Experiment 1, acute caffeine challenge induced a widespread activation of serotonergic neurons throughout the dorsal raphe nucleus (DR); this effect was attenuated in rats that had been exposed to chronic caffeine consumption. In Experiment 2, acute caffeine administration profoundly decreased tph2 and slc22a3 mRNA expression throughout the DR, with no effects on htr1a or slc6a4 mRNA expression. Chronic caffeine exposure for four weeks during adolescence was sufficient to decrease tph2 mRNA expression in the DR measured 28 h after caffeine withdrawal. Chronic caffeine administration during adolescence did not impact the ability of acute caffeine to decrease tph2 or slc22a3 mRNA expression. Together, these data suggest that both chronic caffeine administration during adolescence and acute caffeine challenge during adulthood are important determinants of serotonergic function and serotonergic gene expression, effects that may contribute to chronic effects of caffeine on anxiety-like responses.

Indexed as

Age FactorsAnimalsCaffeineDorsal Raphe NucleusDown-RegulationGene ExpressionMaleOrganic Cation Transporter 3Organic Cation Transport ProteinsRatsReceptor, Serotonin, 5-HT1ASerotonergic NeuronsSerotonin Plasma Membrane Transport ProteinsTryptophan HydroxylaseCaffeineOrganic Cation Transporter 3Organic Cation Transport ProteinsReceptor, Serotonin, 5-HT1ASerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, rattph2 protein, ratTryptophan Hydroxylase

Identifiers

PMID30579884
PMCPMC6438184
OpenAlexW2905803341

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.