Evidence map›Paper›PMID 30579579›Full record

ArticleJournal of biomechanics2019

Paired versus two-group experimental design for rheological studies of vocal fold tissues.

Chet C Xu, Dateng Li, Ted Mau, Elhum McPherson, Mindy Du, Song Zhang

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Chet C XuDepartment of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Graduate Program in Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: chetcxu@gmail.com.
Dateng LiDepartment of Statistical Science, Southern Methodist University, Dallas, TX 75275, USA.
Ted MauDepartment of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Elhum McPhersonDepartment of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Mindy DuDepartment of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Song ZhangDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
The University of Texas Southwestern Medical Center · USSouthern Methodist University · US

Funding

Hybrid scaffold gel for the treatment of vocal fold lamina propria injuryR21DC013363 · NIDCD · UT SOUTHWESTERN MEDICAL CENTER · PI XU, CHET CHE · 2014 to 2015
$505k
Xenogeneic scaffolds for the repair of acute vocal fold lamina propria injuryR03DC011145 · NIDCD · UT SOUTHWESTERN MEDICAL CENTER · PI XU, CHET CHE · 2010 to 2012
$466k
NIDCD NIH HHS R03 DC011145NIDCD NIH HHS R21 DC013363
6 · The paper itself

Abstract

Vibratory function of the vocal folds is largely determined by the rheological properties or viscoelastic shear properties of the vocal fold lamina propria. To date, investigation of the sample size estimation and statistical experimental design for vocal fold rheological studies is nonexistent. The current work provides the closed-form sample size formulas for two major study designs (i.e. paired and two-group designs) in vocal fold research. Our results demonstrated that the paired design could greatly increase the statistical power compared to the two-group design. By comparing the variance of estimated treatment effect, this study also confirms that ignoring within-subject and within-vocal fold correlations during rheological data analysis will likely increase type I errors. Finally, viscoelastic shear properties of intact and scarred rabbit vocal fold lamina propria were measured and used to illustrate theoretical findings in a realistic scenario and project sample size requirement for future studies.

Indexed as

AnimalsBiomechanical PhenomenaFemaleMaleRabbitsRheologyVibrationVocal CordsMixed-effects modelSample sizeSoft tissueStatistical efficiencyViscoelastic shear properties

Identifiers

PMID30579579
PMCPMC6755030
OpenAlexW2902041739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.