ArticleBritish journal of anaesthesia2019
Abnormal calcium signalling and the caffeine-halothane contracture test.
Article in British journal of anaesthesia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Caffeine and human performance: from molecular mechanisms to exercise and recovery.Frontiers in physiology · 2026Review
- Phosphorylation of RYR1 at SerScience signaling · 2025Article
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- Age-Dependent Effects of Muscle Resting Calcium on Fasting Blood Glucose: Implications for Prediabetes Risk.Endocrinology, diabetes & metabolism · 2025Article
- Skeletal muscle disorders as risk factors for type 2 diabetes.Molecular and cellular endocrinology · 2025Review
- Article
- Myopathic manifestations across the adult lifespan of patients with malignant hyperthermia susceptibility: a narrative review.British journal of anaesthesia · 2024Review
- Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue.The Journal of general physiology · 2024Article
- Distinct pathophysiological characteristics in developing muscle from patients susceptible to malignant hyperthermia.British journal of anaesthesia · 2023Article
- Article
- Neuromuscular symptoms in patients withBrain communications · 2022Article
- T lymphocytes from malignant hyperthermia-susceptible mice display aberrations in intracellular calcium signaling and mitochondrial function.Cell calcium · 2021Article
- Impact of statin intake on malignant hyperthermia: an in vitro and in vivo swine study.BMC anesthesiology · 2020Article
- Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes.eLife · 2020Article
- Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals.British journal of anaesthesia · 2019Article
- Predictive factors of the contracture test for diagnosing malignant hyperthermia in a Brazilian population sample: a retrospective observational study.Brazilian journal of anesthesiology (Elsevier)Observational
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe variable clinical presentation of malignant hyperthermia (MH), a disorder of calcium signalling, hinders its diagnosis and management. Diagnosis relies on the caffeine-halothane contracture test, measuring contraction forces upon exposure of muscle to caffeine or halothane (F
methodsAfter institutional ethics committee approval, recruited patients undergoing contracture testing at Toronto's MH centre were assigned to three groups: HH, doubly positive (HS), and negative patients (HN). A clinical index was assembled from musculoskeletal symptoms and signs. An analogous calcium index summarised four measures in cultured myotubes: resting [Ca
resultsThe highest values of both indexes were found in the HH group; the differences in calcium index between HH and the other groups were statistically significant. The principal component analysis confirmed the unique cell-level features of the HH group, and identified elevated resting [Ca
conclusionsThese findings suggest that HH pathogenesis stems from excess Ca
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