ArticleBMC musculoskeletal disorders2018
Articular cartilage gene expression patterns in the tissue surrounding the impact site following applications of shear and axial loads.
Article in BMC musculoskeletal disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Using Dynamic Joint Space During Physiological Loading to Objectively Measure Hip Stability.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Incidence and Risk Factors for Acute Articular Cartilage Tears in Military and Other Occupational Settings: A Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
- Rheometer enabled study of cartilage frequency-dependent properties.Scientific reports · 2020Article
- Effects of Loading Conditions on Articular Cartilage in a Metal-on-Cartilage Pairing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOsteoarthritis is a degradative joint disease found in humans and commercial swine which can develop from a number of factors, including prior joint trauma. An impact injury model was developed to deliver in vitro loads to disease-free porcine patellae in a model of OA.
methodsAxial impactions (2000 N normal) and shear impactions (500 N normal with induced shear forces) were delivered to 48 randomly assigned patellae. The patellae were then cultured for 0, 3, 7, or 14 days following the impact. Specimens in the tissue surrounding the loading site were harvested and expression of 18 OA related genes was studied via quantitative PCR. The selected genes were previously identified from published work and fell into four categories: cartilage matrix, degradative enzymes, inflammatory response, and apoptosis.
resultsType II collagen (Col2a1) showed significantly lower expression in shear vs. axial adjacent tissue at day 0 and 7 (fold changes of 0.40 & 0.19, respectively). In addition, higher expression of degradative enzymes and Fas, an apoptosis gene, was observed in the shear specimens.
conclusionsThe results suggest that a more physiologically valid shear load may induce more damage to surrounding articular cartilage than a normal load alone.
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Registered trials
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