ArticleBMC pediatrics2018
High mortality due to congenital malformations in children aged < 1 year in French Guiana.
Article in BMC pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
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Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparative analysis of burden of topmost disorders requiring rehabilitation services: a systematic review and meta-analysis.Journal of translational medicine · 2025Pooled it
- The burden of congenital heart disease in Malaysia: a comprehensive review and meta-analytic synthesis, 1970-2024.BMC public health · 2025Pooled it
- Infant congenital heart disease prevalence and mortality in French Guiana: a population-based study.Lancet regional health. Americas · 2024Article
- The Epidemiologic Transition in French Guiana: Secular Trends and Setbacks, and Comparisons with Continental France and South American Countries.Tropical medicine and infectious disease · 2023Article
- Aetiological and morphological spectrum of cardiomyopathies in French Guiana: a retrospective study.Open heart · 2020Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundIn French Guiana, pregnant women may be exposed to infectious, environmental, and social risks leading to congenital malformation. The objective of the study was to study mortality rates from congenital malformations among infants < 1 year and to compare them with those in mainland France.
methodsWe used the CEPI DC (INSERM) database, which compiles annual data from death certificates in all French territories using the International Classification of Diseases. Annual deaths for French Guiana and mainland France between 2005 and 2015 were compiled. The age category studied was children less than 1 year and deaths from congenital malformations, deformations and chromosomal abnormalities were compiled. Crude risk ratios and 95% confidence intervals were calculated to quantify the excess risk of disease in French Guiana.
resultsIn French Guiana between 2005 and 2015 there were 666 deaths of children aged < 1 year, among which, 132 (19.8%) were due to congenital malformations and chromosomal anomalies. Overall the risk ratio of death from congenital malformations and chromosomal anomalies between French Guiana and mainland France was 2.7 (1.5-4.7), P < 0.001 for neurological congenital malformations it was 4.8 (1.2-19.7), P = 0.01 and for congenital malformations of the circulatory system it was 3.3 (1.5-6.9), P = 0.001.
conclusionsThe incidence of death from congenital malformations or chromosomal anomalies in French Guiana was significantly higher than in mainland France. Explanations for this may be infections, genetic causes, nutritional causes, and toxic causes that are prevalent. There is a need to identify factors that predispose children born in French Guiana to having a higher risk of congenital malformations and chromosomal anomalies.
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