ArticleBMC musculoskeletal disorders2018
Identification of vitamin D and other bone metabolism parameters as risk factors for primary bone marrow oedema syndrome.
Article in BMC musculoskeletal disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Clinical and Radiological Outcomes of Oral Bisphosphonate Therapy Combined with Conservative Treatment in Subchondral Bone Marrow Edema of the Knee: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Bone Marrow Edema Syndrome as an Emerging Clinical Condition: Investigating the Link with Bone Status-A Single-Center Study.Journal of clinical medicine · 2026Article
- Article
- [Imaging in hip disorders in childhood and adolescence].Orthopadie (Heidelberg, Germany) · 2026Review
- [Nonoperative treatment for the management of osteonecrosis and bone marrow oedema of the foot and ankle].Orthopadie (Heidelberg, Germany) · 2025Article
- [Pharmacological therapy for subchondral pathologies of the knee joint].Orthopadie (Heidelberg, Germany) · 2025Review
- Biopsies from patients with sacral insufficiency fracture are characterized by low bone matrix mineralization and high turnover.JBMR plus · 2024Article
- Advantages of cone beam computed tomography for evaluation of subchondral insufficiency fractures of the knee compared to MRI.Scientific reports · 2024Article
- No Significant Differences between Bisphosphonates and Placebo for the Treatment of Bone Marrow Lesions of the Knee: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2024Review
- Influence of Vitamin D and C on Bone Marrow Edema Syndrome-A Scoping Review of the Literature.Journal of clinical medicine · 2022Article
- Is Primary Bone Marrow Edema of the Knee Associated with Thyroid Disorders? A Retrospective Clinical Study.Journal of clinical medicine · 2022Article
- A novel mutation in collagen gene COL1A2 associated with transient regional osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Evaluation of the relationship between lateral epicondylitis and vitamin D.Joint diseases and related surgery · 2022Article
- Single-Dose Therapy of Zoledronic Acid for the Treatment of Primary Bone Marrow Edema Syndrome.Cureus · 2021Article
- Bone marrow oedema syndrome of the foot and ankle in a paediatric population: a retrospective case series with serial MRI evaluation.Journal of children's orthopaedics · 2020Article
- Zoledronic acid is more efficient than ibandronic acid in the treatment of symptomatic bone marrow lesions of the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Article
- Bone Marrow Foot Oedema in Adolescents: The Role of Vitamin D.Journal of bone metabolism · 2019Article
- Intra-articular osteoid osteoma accompanied by extensive bone marrow edema. A clinical and micro-morphological analysis.Journal of bone oncology · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aetiology and pathogenesis of primary bone marrow oedema syndrome (BMES) remain unclear. This retrospective cross-sectional study in a large cohort of patients with BMES was performed to characterise the overall skeletal status and turnover in patients with BMES, with the aim of identifying risk factors for this disease.
methodsPatients who were diagnosed with BMES on the basis of clinical and radiological (magnetic resonance imaging) findings in our outpatient clinic were identified retrospectively. Patient history, co-existing metabolic disorders, bone metabolism parameters (serum calcium, phosphate, 25-OH-D
resultsOf the 171 patients, 65 were identified without secondary cause for BMES. Of the 65 patients, 61.5% were female. The mean age was 49.5 ± 16.7 years, and age-related BMES prevalence showed two peaks, one in adolescence (11-20 years) and one at an older age (51-70 years). BMES predominantly affected the weight-bearing joints, namely, the ankle/foot (55.1%), knee (22.4%) and proximal femur (16.3%). Thyroid disorders and secondary hyperparathyroidism were highly prevalent (21.5 and 21.4%, respectively). On average, the cohort had elevated deoxypyridinoline levels and low 25-OH-D
conclusionsBMES is associated with high bone turnover. Patients who are diagnosed with BMES should be screened carefully for bone metabolism disorders and their potential risk factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.