Evidence map›Paper›PMID 30578877›Full record

ArticleThe Journal of allergy and clinical immunology2019

Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults.

Amber Dahlin, Joanne E Sordillo, John Ziniti, Carlos Iribarren, Meng Lu, Scott T Weiss, Kelan G Tantisira, Quan Lu, Mengyuan Kan, Blanca E Himes and 2 more

Abstract readLetter
In one paragraph

Article in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Functional Variant Discovery Identifies a Novel Genetic Link between SPRY2, Wood Smoke, and Asthma.American journal of respiratory cell and molecular biology · 2026
    Article
  2. Article
  3. Article
  4. Genetics of chronic respiratory disease.Nature reviews. Genetics · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Genetics and Epigenetics in Asthma.International journal of molecular sciences · 2021
    Review
  10. Review
  11. Association ofFrontiers in cell and developmental biology · 2021
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Advances in asthma and allergic disease genetics: Is bigger always better?The Journal of allergy and clinical immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Amber DahlinChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Joanne E SordilloPRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Mass.
John ZinitiChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Carlos IribarrenDivision of Research, Kaiser Permanente Northern California, Oakland, Calif.
Meng LuDivision of Research, Kaiser Permanente Northern California, Oakland, Calif.
Scott T WeissChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Partners Center for Personalized Medicine, Partners Health Care, Boston, Mass.
Kelan G TantisiraChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Partners Center for Personalized Medicine, Partners Health Care, Boston, Mass.
Quan LuDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass; Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, Mass.
Mengyuan KanDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pa.
Blanca E HimesDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pa.
Eric JorgensonDivision of Research, Kaiser Permanente Northern California, Oakland, Calif.
Ann Chen WuChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Mass. Electronic address: Ann.Wu@childrens.harvard.edu.

Funding

THE PHARMACOGENETICS OF ASTHMA TREATMENTU01HL065899 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G, WEISS, SCOTT T · 2000 to 2014
$38.5M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
CEBPD-Mediated Mechanisms of Glucocorticoid Insensitivity in Severe AsthmaR01HL133433 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HIMES, BLANCA E · 2017 to 2021
$3.2M
Age-Dependent Pharmacogenomics of Asthma Treatment (ADAPT)R01HD085993 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI WU, ANN CHEN · 2016 to 2020
$3.1M
Genetic Etiology of Abdominal Hernia SusceptibilityR01DK116738 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI AHITUV, NADAV, CHOQUET, HELENE · 2018 to 2020
$1.8M
GENOMICS AND PHARMACOGENOMICS OF SYMPTOMS IN ASTHMAR01NR013391 · NINR · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2011 to 2013
$1.3M
Role of microRNA molecules in therapeutic response to leukotriene modifying agents in asthmaK01HL130629 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DAHLIN, AMBER · 2016 to 2020
$818k
NHLBI NIH HHS K01 HL130629NHLBI NIH HHS R01 HL133433NHLBI NIH HHS U01 HL065899NICHD NIH HHS R01 HD085993NIEHS NIH HHS P30 ES013508
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAsthmaFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMalePolymorphism, Single Nucleotide

Identifiers

PMID30578877
PMCPMC6451881

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.