Evidence map›Paper›PMID 30578684›Full record

ArticleJournal of medical virology2019

Cytomegalovirus shedding from breastmilk and mucosal sites in healthy postpartum women: A pilot study.

Tali Azenkot, Benjamin Zaniello, Margaret L Green, Stacy Selke, Meei-Li Huang, Amalia Magaret, Anna Wald, Christine Johnston

Open access · greenAbstract read
In one paragraph

Article in Journal of medical virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Immune surveillance of cytomegalovirus in tissues.Cellular & molecular immunology · 2024
    Review
  3. Human cytomegalovirus and neonatal infection.Current research in microbial sciences · 2024
    Review
  4. Review
  5. Observational
  6. Article
  7. Cytomegalovirus (CMV) Pneumonitis: Cell Tropism, Inflammation, and Immunity.International journal of molecular sciences · 2019
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Tali AzenkotUniversity of California, Davis, UC Davis School of Medicine, Davis, CA.
Benjamin ZanielloProvidence Health and Services, Seattle, WA.
Margaret L GreenDepartments of Medicine and Laboratory Medicine, University of Washington, Seattle, WA.
Stacy SelkeDepartments of Medicine and Laboratory Medicine, University of Washington, Seattle, WA.
Meei-Li HuangDepartments of Medicine and Laboratory Medicine, University of Washington, Seattle, WA.
Amalia MagaretDepartments of Medicine and Laboratory Medicine, University of Washington, Seattle, WA.
Anna WaldDepartments of Medicine and Laboratory Medicine, University of Washington, Seattle, WA.
Christine JohnstonDepartments of Medicine and Laboratory Medicine, University of Washington, Seattle, WA.ORCID 0000-0002-3073-0843
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAUniversity of Washington · USProvidence Health & Services · USUniversity of California, Davis · US

Funding

THE PERINATAL COMPLICATIONS OF ASYMPTOMATIC GENITAL HERPES SIMPLEX VIRUSP01AI030731 · NIAID · UNIVERSITY OF WASHINGTON · PI WALD, ANNA · 1991 to 2017
$34.3M
Clinical Research in HSV InfectionsK24AI071113 · NIAID · UNIVERSITY OF WASHINGTON · PI WALD, ANNA · 2006 to 2015
$1.7M
NIAID NIH HHS K24 AI071113NIAID NIH HHS P01 AI030731
6 · The paper itself

Abstract

Mother-to-child cytomegalovirus (CMV) breastmilk transmission can occur in the postnatal period. In a pilot study, we measured daily CMV detection by polymerase chain reaction in breastmilk, vaginal, and saliva samples from nine healthy CMV-seropositive postpartum women for 28 days. CMV was found in seven of nine women and 171 of 253 breastmilk samples (67.6%). In four women, all breastmilk samples were positive. CMV was less frequently detected in the vagina (39 of 258, 15.1%) and saliva (53 of 258, 20.5%). Daily breastmilk, oral, and genital collection is feasible and demonstrates high variability between women. Further study of the dynamics of CMV in distinct anatomic compartments is warranted.

Indexed as

Healthy VolunteersPostpartum PeriodVirus SheddingAdolescentAdultCytomegalovirusFemaleHumansInfantInfant, NewbornMilk, HumanPilot ProjectsPolymerase Chain ReactionSalivaVaginaYoung Adultbreastmilkcytomegaloviruspostpartum

Identifiers

PMID30578684
PMCPMC6402967
OpenAlexW2905850247

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.