Trial reportThe Journal of physiology2019
Manipulation of mechanical ventilatory constraint during moderate intensity exercise does not influence dyspnoea in healthy older men and women.
Trial report in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- The Physiological Effects of Face Masks During Exercise Worn Due to COVID-19: A Systematic Review.Sports healthPooled it
- The acute respiratory response to blood-flow restriction resistance exercise in healthy adults: A randomized crossover trial.Physiological reports · 2026Trial
- Influence of graded hypercapnia on endurance exercise performance in healthy humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Trial
- Current limits for flowmeter resistance in metabolic carts can negatively affect exercise performance.Physiological reports · 2021Trial
- Stimulus-dependent sex differences in dyspnoea: Mechanical loading vs. hypercapnia.Experimental physiology · 2026Article
- The Appropriateness of Medical Devices Is Strongly Influenced by Sex and Gender.Life (Basel, Switzerland) · 2024Review
- Breathing a low-density gas reduces respiratory muscle force development and marginally improves exercise performance in master athletes.European journal of applied physiology · 2024Article
- Sex, gender and the pulmonary physiology of exercise.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Face Masks and the Cardiorespiratory Response to Physical Activity in Health and Disease.Annals of the American Thoracic Society · 2021Review
- Effects of wearing facemasks on the sensation of exertional dyspnea and exercise capacity in healthy subjects.PloS one · 2021Article
- Is the healthy respiratory system built just right, overbuilt, or underbuilt to meet the demands imposed by exercise?Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Minimizing airflow turbulence in women lowers the work of breathing to levels similar to men.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Analysis of maximal expiratory flow-volume curves in adult survivors of preterm birth.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsThe perceived intensity of exertional breathlessness (i.e. dyspnoea) is higher in older women than in older men, possibly as a result of sex-differences in respiratory system morphology. During exercise at a given absolute intensity or minute ventilation, older women have a greater degree of mechanical ventilatory constraint (i.e. work of breathing and expiratory flow limitation) than their male counterparts, which may lead to a greater perceived intensity of dyspnoea. Using a single-blind randomized study design, we experimentally manipulated the magnitude of mechanical ventilatory constraint during moderate-intensity exercise at ventilatory threshold in healthy older men and women. We found that changes in the magnitude of mechanical ventilatory constraint within the physiological range had no effect on dyspnoea in healthy older adults. When older men and women perform moderate intensity exercise, mechanical ventilatory constraint does not contribute significantly to the sensation of dyspnoea. ABSTRACT: We aimed to determine the effect of manipulating mechanical ventilatory constraint during submaximal exercise on dyspnoea in older men and women. Eighteen healthy subjects (aged 60-80 years; nine men and nine women) completed two days of testing. On day 1, subjects were assessed for pulmonary function and performed a maximal incremental cycle exercise test. On day 2, subjects performed three 6-min bouts of cycling at ventilatory threshold, in a single-blind randomized manner, while breathing: (i) normoxic helium-oxygen (HEL) to reduce the work of breathing (W
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.