ArticleAging cell2019
Asymmetrical subcortical plasticity entails cognitive progression in older individuals.
Article in Aging cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Brain asymmetry is globally different in males and females: exploring cortical volume, area, thickness, and mean curvature.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A novel method for estimating connectivity-based parcellation of the human brain from diffusion MRI: Application to an aging cohort.Human brain mapping · 2022Article
- Intra- and interhemispheric symmetry of subcortical brain structures: a volumetric analysis in the aging human brain.Brain structure & function · 2022Article
- Structural and functional brain asymmetries in the early phases of life: a scoping review.Brain structure & function · 2022Article
- Reorganization of brain structural networks in aging: A longitudinal study.Journal of neuroscience research · 2021Article
- Biological laterality and peripheral nerve DTI metrics.PloS one · 2021Article
- Article
- Asymmetrical subcortical plasticity entails cognitive progression in older individuals.Aging cell · 2019Article
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Authors and funding
13 authors.
Funding
Abstract
Structural brain asymmetries have been associated with cognition. However, it is not known to what extent neuropsychological parameters and structural laterality covary with aging. Seventy-five subjects drawn from a larger normal aging cohort were evaluated in terms of MRI and neuropsychological parameters at two moments (M1 and M2), 18 months apart. In this time frame, asymmetry as measured by structural laterality index (ΔLI) was stable regarding both direction and magnitude in all areas. However, a significantly higher dispersion for this variation was observed in subcortical over cortical areas. Subjects with extreme increase in rightward lateralization of the caudate revealed increased M1 to M2 Stroop interference scores, but also a worsening of general cognition (MMSE). In contrast, subjects showing extreme increase in leftward lateralization of the thalamus presented higher increase in Stroop interference scores. In conclusion, while a decline in cognitive function was observed in the entire sample, regional brain asymmetries were relatively stable. Neuropsychological trajectories were associated with laterality changes in subcortical regions.
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