Evidence map›Paper›PMID 30578590›Full record

ArticleClinical transplantation2019

Disparity in access to kidney allograft offers among transplant candidates with human immunodeficiency virus.

Jordana B Cohen, Jayme E Locke, Brittany Shelton, Rhiannon D Reed, Margaux Mustian, Paul MacLennan, Kimberly A Forde, Peter P Reese, Deirdre Sawinski

Abstract read
In one paragraph

Article in Clinical transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Infections After Kidney Transplantation From Donors With HIV to Recipients With HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Observational
  2. Review
  3. Article
  4. Safety of Kidney Transplantation from Donors with HIV.The New England journal of medicine · 2024
    Observational
  5. Article
  6. Article
  7. Article
  8. A prospective multicenter pilot study of HIV-positive deceased donor to HIV-positive recipient kidney transplantation: HOPE in action.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Organ transplantation in persons with HIV.AIDS (London, England) · 2020
    Review
  13. Barriers to kidney transplant evaluation in HIV-positive patients with advanced kidney disease: A single-center study.Transplant infectious disease : an official journal of the Transplantation Society · 2020
    Article
  14. Review
  15. Article
  16. Article
  17. Trends over Time in Practice and Outcomes of Lung Transplantation in Recipients With Human Immunodeficiency Virus.Transplant infectious disease : an official journal of the Transplantation Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jordana B CohenRenal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0003-4649-079X
Jayme E LockeDepartment of Surgery, University of Alabama at Birmingham Comprehensive Transplant Institute, Birmingham, Alabama.
Brittany SheltonDepartment of Surgery, University of Alabama at Birmingham Comprehensive Transplant Institute, Birmingham, Alabama.
Rhiannon D ReedDepartment of Surgery, University of Alabama at Birmingham Comprehensive Transplant Institute, Birmingham, Alabama.
Margaux MustianDepartment of Surgery, University of Alabama at Birmingham Comprehensive Transplant Institute, Birmingham, Alabama.
Paul MacLennanDepartment of Surgery, University of Alabama at Birmingham Comprehensive Transplant Institute, Birmingham, Alabama.
Kimberly A FordeCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Peter P ReeseRenal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0003-1440-069X
Deirdre SawinskiRenal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Funding

Management of hypertension in obesity: Antihypertensive class effects, blood pressure control, and renal and cardiac outcomesK23HL133843 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI COHEN, JORDANA B. · 2016 to 2020
$945k
Waiting List and Kidney Transplant Outcomes for Patients with Hepatitis C InfectionR21DK108045 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI REESE, PETER PHILIP, SAWINSKI, DEIRDRE · 2017 to 2018
$461k
NHLBI NIH HHS K23 HL133843NIDDK NIH HHS R21 DK108045
6 · The paper itself

Abstract

backgroundDespite a survival benefit from transplantation and acceptable outcomes, patients with human immunodeficiency virus (HIV+) face barriers to kidney transplantation. Little is known about the acceptance or decline of organ offers on their behalf because waitlist registry data do not include HIV serostatus.

methodsWe performed a retrospective cohort study using match run data from the Organ Procurement and Transplantation Network, including every kidney offer from May 1, 2007, to July 3, 2013. HIV and hepatitis C virus (HCV) serostatus were obtained by merging the match run with clinical data from a large dialysis provider. We used Cox proportional hazards modeling to evaluate differences in time to the first organ offer and to transplantation. A total of 35 646 uninfected, 2213 HCV+, 418 HIV+, and 71 HIV+/HCV+ candidates received organ offers during the study period.

resultsCompared to uninfected candidates, HIV+ candidates had a significantly lower likelihood of receiving a first offer (adjusted hazard ratio [aHR] 0.88, 95% confidence interval [CI] 0.79-0.99) and undergoing transplantation (aHR 0.82, 95% CI: 0.68-0.98) after receiving a first offer; HCV+ candidates had a similar likelihood of receiving a first offer (aHR 0.98, 95% CI: 0.92-1.03) and greater likelihood of transplantation after receiving a first offer (aHR 1.23, 95% CI: 1.12-1.36).

conclusionsHIV+ candidates had a significantly longer wait until their first organ offer and to transplantation. Efforts to increase their access to transplantation are needed.

Indexed as

Health Services AccessibilityWaiting ListsAdultAgedAged, 80 and overFemaleFollow-Up StudiesHealthcare DisparitiesHIVHIV InfectionsHumansMaleMiddle AgedRetrospective StudiesTissue and Organ ProcurementTissue Donorshepatitis C virushuman immunodeficiency viruskidney transplantationorgan allocation

Identifiers

PMID30578590
PMCPMC6386602

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.