ArticleActa neurochirurgica2019
Treatment and survival of osteosarcoma and Ewing sarcoma of the skull: a SEER database analysis.
Article in Acta neurochirurgica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Pediatric versus adult cases of primary osseous sarcomas of the spine: A population-based analysis.North American Spine Society journal · 2026Article
- Epidemiology and Prognosis of Patients With Osteosarcoma at Different Primary Sites: A SEER Population-Based Study.Cancer reports (Hoboken, N.J.) · 2026Article
- Treatment outcomes of paediatric chest wall Ewing's sarcoma; report from tertiary care cancer center.Ecancermedicalscience · 2026Article
- Osteosarcoma and Ewing sarcoma of the skull in children and adolescents: a population-based study.Acta neurochirurgica · 2025Article
- Single-Session Surgical Intervention with Resection of a Primary Cranial Osteosarcoma and Cranioplasty using a 3D-Printed Craniotomy Template and Cranioplasty Molds.Journal of neurological surgery reports · 2025Article
- Primary Ewing's Sarcoma affecting the Central Nervous System: A single-center experience and Narrative review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Extent of Surgery and Survival of Osteosarcoma: A Retrospective Population-Based Study.Cureus · 2024Article
- Prognostic analysis and clinical characteristics of osteosarcoma and Ewing sarcoma of the rib, sternum, and clavicle: a SEER-based study.The Journal of international medical research · 2023Article
- Malignant Brain and Spinal Tumors Originating from Bone or Cartilage.Advances in experimental medicine and biology · 2023Article
- Comprehensive conservative treatment for multiple metastases of skull osteosarcoma: A case report.Frontiers in neurology · 2023Article
- Primary intracranial extraosseous Ewing's sarcoma of the skull base in an elderly adult: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Primary Calvarial Ewing Sarcoma: A Case Series.Journal of neurological surgery. Part B, Skull base · 2022Article
- Primary Ewing sarcoma/peripheral primitive neuroectodermal tumors in the cranial bone and mobile spine: what is the difference?BMC surgery · 2022Article
- Systemic treatment for primary malignant sarcomas arising in craniofacial bones.Frontiers in oncology · 2022Review
- TMED3/RPS15A Axis promotes the development and progression of osteosarcoma.Cancer cell international · 2021Article
- CaCancer science · 2021Article
- Primary osteosarcoma of the parietal bone.Skeletal radiology · 2021Article
- Review
- An update on the roles of circular RNAs in osteosarcoma.Cell proliferation · 2021Review
- Prognostic factors in osteosarcoma: A study level meta-analysis and systematic review of current practice.Journal of bone oncology · 2020Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCommon primary bone tumors include osteosarcomas (OSC) and Ewing sarcomas (EWS). The skull is a rare site, and literature about their treatment and survival is scarce. Using the Surveillance, Epidemiology, and End Results (SEER) database, this study aims to assess the treatment and survival of skull OSC and skull EWS, as well as predictors for survival.
methodsSkull OSC and EWS cases were obtained from the SEER database. Patient and tumor characteristics, treatment modalities, and survival were extracted. Overall survival (OS) was assessed using multivariable Cox proportional hazard regression stratified by tumor histology. Kaplan-Meier curves were constructed for OS comparing OSC and EWS, as well as histological subtypes in OSC.
resultsA total of 321 skull OSC and 80 skull EWS patients were registered from 1973 to 2013. EWS was more common in younger patients (p < 0.001). Resection was the predominant treatment strategy (80.1%), frequently in combination with adjuvant radiotherapy (30.4%). The 5-year survival rate varied significantly between OSC and EWS (51.0% versus 68.5%, p = 0.02). Kaplan-Meier curves show that EWS had a significantly better survival compared to OSC. Comparing histological subtypes of skull OSC, chondroblastic OSC had the best OS, Paget OSC the worst. Older age, tumor advancement, no surgical treatment, and the use of radiotherapy were identified as independent predictors of decreased OS in skull OSC.
conclusionOverall prognosis is better for EWS compared to OSC. Chondroblastic OSC have the best overall survival, while OSC associated with Paget's disease of the bone has the poorest overall survival.
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